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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #177691
Title: THE EFFECT OF VITAMIN E ON SECONDARY BACTERIAL INFECTION AFTER INFLUENZA INFECTION IN YOUNG AND OLD MICE

Author
item GAY, RAINA - TUFTS/HNRCA
item HAN, SUNG NIM - TUFTS/HNRCA
item MARKO, MELISSA - TUFTS/HNRCA
item BELISLE, SARAH - TUFTS/HNRCA
item BRONSON, RODERICK - TUFTS SCH VETERINARY MED
item MEYDANI, SIMIN - TUFTS/HNRCA

Submitted to: Annals of the New York Academy of Sciences
Publication Type: Proceedings
Publication Acceptance Date: 11/18/2004
Publication Date: 12/14/2004
Citation: Gay, R., Han, S., Marko, M., Belisle, S., Bronson, R., Meydani, S.N. 2004. The effect of vitamin E on secondary bacterial infection after influenza infection in young and old mice. In: Annals of the New York Academy Of Sciences. Vitamin E and Health Symposium, May 22-24, 2004, Boston, Massachusetts, USA. p. 1031:418-421

Interpretive Summary:

Technical Abstract: Mortality from influenza is high in the elderly. Deaths are mainly due to secondary complications, including Staphylococcus aureus (SA) infections. Vitamin E (E) supplementation reduces influenza in aged mice. This study determined the efficacy of E supplementation on secondary bacterial infections following influenza in young and old mice. C57BL/6 mice were fed diets containing 30 or 500 ppm E for 4 weeks. Priming with influenza significantly increased SA in the lungs of infected mice fed control diet. Age did not have a significant effect on SA infection alone or SA infection following influenza infection. E supplementation did not have a significant effect on SA infection alone. However, E supplementation abolished the priming effect of influenza on SA.