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Submitted to: Pacifichem Symposium
Publication Type: Abstract Only Publication Acceptance Date: 6/1/2005 Publication Date: 12/15/2005 Citation: Erhan, S.Z., Liu, Z. 2005. Development of thermosensitive polymers for control release systems [abstract]. PacifiChem 2005, December 15-20, 2005, Honolulu, Hawaii. p. 685. Interpretive Summary: Technical Abstract: Hydrogels as drug carriers are able to provide a set of advantages due to their physical properties’ resemblance to living tissue. Therefore, they have been widely used in controlled release systems. Hydrogels that swell and contract in response to external pH are being explored. The pH sensitive hydrogels have a potential use in the site-specific delivery of drugs to the diseased lesions and have been prepared for low molecular weight and protein drug delivery. It is well known that the release of drugs from hydrogels depends on their structure or their chemical properties in response to the environmental pH. Pluronic molecules, copolymers of ethylene oxide and propylene oxide, are used in drug controlled systems. By controlling molecular weight and propylene oxide content, the surface active properties of the compound can be changed for a specific application. Based on the idea of a combination of hydrophilic and hydrophobic copolymers, we designed a molecular structure of polymers that has a similar function as Pluronic molecules. These polymers show very good surface active properties. This approach is technically and economically available. The primary drug release study shows that these polymers are temperature sensitive, which is an important property for a drug release system. |
