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Title: STRUCTURALLY INTEGRATED ORGANIC LIGHT-EMITTING DEVICE (OLED)-BASED SENSORS FOR INDUSTRIAL AND ENVIRONMENTAL SECURITY: SENSORS FOR HYDRAZINE AND ANTHRAX

Author
item ZHOU, ZHAOQUN - IOWA STATE UNIVERSITY
item SHINAR, RUTH - IOWA STATE UNIVERSITY
item CHOUDHURY, BHASKAR - IOWA STATE UNIVERSITY
item Tabatabai, Louisa
item LIAO, CHUXIONG - IOWA STATE UNIVERSITY
item SHINAR, JOSEPH - IOWA STATE UNIVERSITY

Submitted to: International Society for Optical Engineering
Publication Type: Proceedings
Publication Acceptance Date: 10/25/2005
Publication Date: 12/13/2005
Citation: Zhou, Z., Shinar, R., Choudhury, B., Tabatabai, L.B., Liao, C., Shinar, J. 2005. Structurally integrated organic light-emitting device (oled)-based sensors for industrial and environmental security: sensors for hydrazine and anthrax. Proceedings of the International Society for Optical Engineering. 5994:1-9.

Interpretive Summary: A photoluminescent sensors are described for the detection of an industrial pollutant, hydrazine, and for the detection of the enzyme, lethal factor, of the anthrax bacillus. The hydrazine sensor is based on the luminescent product of the reaction of hydrazine with an anthracene derivative. The anthrax sensor is based on the luminescence produced after cleavage of a labeled peptide substrate for the lethal factor enzyme.

Technical Abstract: The application of the new compact platform of structurally integrated, photoluminescent (bio)chemical sensors, where the photoluminescence (PL) excitation source is an OLED, to the detection of hydrazine and anthrax, is described. The hydrazine sensor is based on the reaction between nonluminescent anthracene-2,3-dicarboxaldehyde and hydrazine or hydrazine sulfate, which generates a luminescent product. The anthrax sensor is based on a Förster resonance energy transfer (FRET) assay, where the anthrax-secreted lethal factor enzyme cleaves certain labeled peptides at a specific site. The cleaving separates the FRET donor-acceptor pair, resulting in an increase in the PL of the donor, which was previously absorbed by the acceptor.