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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Ruminant Diseases and Immunology Research » Research » Publications at this Location » Publication #192094
Title: HIGH GROWTH RATE FAILS TO ENHANCE ADAPTIVE IMMUNE RESPONSES OF NEONATAL CALVES AND IS ASSOCIATED WITH DECREASED T CELL VIABILITY

Author
item FOOTE, MONICA - IOWA STATE UNIVERSITY
item Nonnecke, Brian
item Waters, Wade
item BEITZ, DONALD - IOWA STATE UNIVERSITY
item FOWLER, MICHAEL - LAND O'LAKES INC
item JOHNSON, T - LAND O'LAKES INC
item MILLER, B - LAND O'LAKES INC

Submitted to: Joint Meeting of the ADSA, AMSA, ASAS and PSA
Publication Type: Abstract Only
Publication Acceptance Date: 2/18/2006
Publication Date: 7/9/2006
Citation: Foote, M.R., Nonnecke, B.J., Waters, W.R., Beitz, D.C., Fowler, M.A., Johnson, T.E., Miller, B.L. 2006. High growth rate fails to enhance adaptive immune responses of neonatal calves and is associated with decreased T cell viability [abstract]. American Dairy Science Association-American Society of Animal Science 2006 Joint Annual Meeting. p. 163.

Interpretive Summary:

Technical Abstract: The objective of the study was to evaluate effects of three targeted growth rates [No Growth (or maintenance, NG), Low Growth (LG), and High Growth (HG)] on adaptive (antigen-specific) immune responses of preruminant calves vaccinated with Mycobacterium bovis bacillus Calmette-Guerin (BCG) and ovalbumin (OVA) 3 wks after initiation of dietary treatments. Growth rates for NG (.11 kg/d), LG (.58 kg/d), and HG (1.16 kg/d) calves differed (P < .001) throughout the experimental period. Blood leukocyte populations from HG calves had lower (P .05) percentages of CD45RO+ (memory) CD4+ and CD8+ T cells, OVA-specific serum IgG1 and 2 concentrations, or PPD-induced interferon-gamma and nitric oxide (NO) secretion by MNL. Antigen (i.e., PPD)-elicited delayed-type hypersensitivity responses of NG and HG calves were similar (P > .05) and exceeded (P