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Title: GLUCOSE AND INSULIN RESPONSES TO WHOLE GRAIN BREAKFASTS VARYING IN SOLUBLE FIBER-A DOSE RESPONSE STUDY IN OBESE WOMEN WITH INSULIN RESISTANCE

Author
item KIM, HYUNSOOK
item BEHALL, KAY
item CONWAY, JOAN

Submitted to: Obesity Research
Publication Type: Abstract Only
Publication Acceptance Date: 7/5/2006
Publication Date: 10/3/2006
Citation: Hyunsook, K., Behall, K., and Conway, J.M. 2006. Clucose and Insulin Responses to Whole Grain Breakfasts Varying in Soluble Fiber-A Dose Response Study in Obese Women with Insulin Resistance. 2006. Obesity Research. 14:A168.

Interpretive Summary: n/a

Technical Abstract: High intakes of soluble fiber have been shown to moderate glucose and insulin responses to a meal. In order to test the linearity of this response to the soluble fiber beta-glucan we studied 21 normoglycemic women who met the criteria for insulin resistance and were (mean ± SD) 50 ± 10 years of age with a BMI of 34.1 ± 4.41. Six treatments were fed in a Latin-square design and consisted of either water or a hot cereal breakfast meal of wheat, barley or combinations of wheat and barley to provide 5 levels of beta-glucan (0, 2.5, 5, 7.5, and 10 g). Blood samples were obtained before and 30, 60, 120 and 180 minutes after breakfast. Plasma glucose and insulin were determined and 2-hour areas under the curve (AUC) were calculated. Preliminary analysis indicates that while the glucose responses to the whole grain cereal meals were blunted as compared to a 2 hour oral glucose tolerance test, there was no significant difference in the glucose responses or in the glucose AUC following these 5 breakfasts. However there were significant reductions in the insulin responses and in the insulin AUC following the breakfasts containing 2.5, 5, 7.5, and 10 gram of beta-glucan. Normal levels of glucose were maintained at lower levels of insulin secretion when the subjects consumed breakfasts containing at least 2.5 g of beta-glucan. This agrees with work of others that indicates that high fiber intakes improve insulin sensitivity. Therefore consuming a diet rich in soluble fiber, such as beta-glucan, would have significant impact on lowering the risk for type 2 diabetes.