Skip to main content
ARS Home » Research » Publications at this Location » Publication #196600
Title: CURRENT STATUS OF RECOMBINANT MAREK'S DISEASE VACCINES FOR CONTROL OF FUTURE OUTBREAKS

Author
item Lee, Lucy
item Silva, Robert
item REDDY, SANJAY - TEXAS A & M UNIVERSITY

Submitted to: Workshop on Molecular Pathogenesis of Marek's Disease and Avian Immunology
Publication Type: Abstract Only
Publication Acceptance Date: 8/5/2006
Publication Date: 8/5/2006
Citation: Lee, L.F., Silva, R.F., Reddy, S. 2006. Current status of recombinant Marek's disease vaccines for control of future outbreaks [abstract]. 4th International Workshop on Molecular Pathogenesis of Marek's Disease Virus. p. 43.

Interpretive Summary:

Technical Abstract: More than 4 decades of vaccination has resulted in good control of Marek’s disease (MD). Although vaccination has dramatically reduced the incidence of the disease, more virulent viruses are emerging and the development of new control strategies is needed. Recently, the student of MD virus (MDV) gene function was greatly facilitated by developing new methods for the generation of recombinant MDV using overlapping cosmid clone DNAs and/or the bacterial artificial chromosomes (BACs). We have used MDV cosmid clones SN5, P89, SN16, A6 and B40, from the very virulent strain, Md5, encompassing the entire MDV genome to generate recombinant rMd5 viruses lacking the various MDV unique genes. Several gene deletion mutants of MDV including rMd5/delta-pp38, rMd5/delta-vIL8, rMd5/delta-Meq, and rMd5/delta-LORF11 were generated and protective efficacies were compared in chickens. Some of these mutants have great potential for protecting chickens against tumor development and can be candidate vaccine for future MD outbreaks.