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ARS Home » Research » Publications at this Location » Publication #197413
Title: THE ROLE OF INTERGENIC SEQUENCES IN PATHOGENESIS OF NEWCASTLE DISEASE VIRUS

Author
item YAN, YONGQI - VA-MD REG.COLL OF VET MED
item King, Daniel
item SAMAL, SIBA - VA-MD REG.COLL OF VET MED

Submitted to: American Veterinary Medical Association Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/7/2006
Publication Date: 7/15/2006
Citation: Yan, Y., King, D.J., Samal, S.K. 2006. The role of intergenic sequences in pathogenesis of Newcastle disease virus [abstract]. American Veterinary Medical Association Abstract. p. 158.

Interpretive Summary:

Technical Abstract: Newcastle disease is an important infectious disease of poultry worldwide. The virulence and pathogenesis of Newcastle Disease Virus (NDV) are not well understood. We have examined the role of the non-transcribed intergenic sequences (IGS) in NDV transcription and pathogenesis. Several recombinant NDVs with altered intergenic regions, both in length and sequence, were generated by reverse genetic techniques. The level of transcription of mRNAs from these recombinant viruses was compared to that of the parental virus. Pathogenesis and virulence of the recombinant NDVs were evaluated in chickens. Our results showed that the IGS can modulate the pathogenesis of NDV.