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ARS Home » Southeast Area » Stoneville, Mississippi » Warmwater Aquaculture Research Unit » Research » Publications at this Location » Publication #199953
Title: A Novel Family of Diversified Immunoregulatory Receptors in Teleosts is Homologous to Both Mammalian Fc Receptors and Molecules Encoded Within the Leukocyte Receptor Complex

Author
item STAFFORD, J - U. OF MISS. MEDICAL CTR.
item BENGTEN, E - U. OF MISS. MEDICAL CTR.
item DU PASQUIER, L - UNIVERSITY OF BASEL
item MCINTOSH, R - U. OF MISS. MEDICAL CTR.
item Quiniou, Sylvie
item CLEM, L - U. OF MISS. MEDICAL CTR.
item MILLER, N - U. OF MISS. MEDICAL CTR.
item WILSON, M - U. OF MISS. MEDICAL CTR.

Submitted to: Immunogenetics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/23/2006
Publication Date: 7/15/2006
Citation: Stafford, J.L., Bengten, E., Du Pasquier, L., Mcintosh, R.D., Quiniou, S.M., Clem, L.W., Miller, N.W., Wilson, M. 2006. A novel family of diversified immunoregulatory receptors in teleosts is homologous to both mammalian fc receptors and molecules encoded within the leukocyte receptor complex. Immunogenetics 59:758-773.

Interpretive Summary: The knowledge of fish immune system is limited. This study relates the discovery of three novel molecules in catfish (LITRs) by DNA sequencing. These molecules are akin to the mammalian Ig-like receptors which are molecules involved in the innate response. This information provides basic information toward a better understanding of the catfish immune system and its role in response to pathogens.

Technical Abstract: Three novel and closely related leukocyte immune-type receptors (IpLITR) have been identified in channel catfish (Ictalurus punctatus). These receptors belong to a large polymorphic and polygenic subset of the Ig superfamily with members located on at least three independently segregating loci. Like mammalian and avian innate immune regulatory receptors, IpLITRs have both putative inhibitory and stimulatory forms, with multiple types coexpressed in various lymphoid tissues and clonal leukocyte cell lines. IpLITRs have an unusual and novel relationship to mammalian and avian innate immune receptors: the membrane distal Ig domains of an individual IpLITR are related to fragment crystallizable receptors (FcRs) and FcR-like proteins, whereas the membrane proximal Ig domains are related to several leukocyte receptor complex encoded receptors. This unique composition of Ig domains within individual receptors supports the hypothesis that functionally and genomically distinct immune receptor families found in tetrapods may have evolved from such ancestral genes by duplication and recombination events. Furthermore, the discovery of a large heterogeneous family of immunoregulatory receptors in teleosts, reminiscent of amphibian, avian, and mammalian Ig-like receptors, suggests that complex innate immune receptor networks have been conserved during vertebrate evolution.