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Title: Development of a web services based system for dissemination of single nucleotide polymorphism data

Author
item Heaton, Michael - Mike
item MORRIS, JOSEPH - UNIV. OF LOUISVILLE
item ELTONSY, NEVINE - UNIV. OF LOUISVILLE
item ROUCHKA, ERIC - UNIV. OF LOUISVILLE
item KALBFLEISCH, TED - UNIV. OF LOUISVILLE

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 10/3/2006
Publication Date: 1/2/2007
Citation: Heaton, M.P., Morris, J., Eltonsy, N., Rouchka, E., Kalbfleisch, T. 2007. Development of a web services based system for dissemination of single nucleotide polymorphism data [abstract]. Plant and Animal Genome XV Conference. Poster No. P517.

Interpretive Summary:

Technical Abstract: Single nucleotide polymorphisms (SNPs) can be used to generate DNA-based fingerprints for individual identification. The efficiency of DNA fingerprinting is greatest when the frequency of both SNP alleles is near 0.50. A number of SNPs have been identified in cattle populations with minor allele frequencies greater than 0.40. Genotypes from those SNPs can be used to track tissues, trace animal origin, and determine parentage. In order to make this data accessible to scientists who are interested in developing assays for inexpensive genotyping tests, it has become necessary to develop a web services based system that will store, retrieve, and analyze the data being experimentally generated. This data includes breed information for the cattle analyzed, upstream and downstream flanking sequence for the SNPs, and trace data for confirmation of the genotype calls which led to the SNP discovery. This data will be available through web services application programming interfaces (APIs) such that it is straightforward to write independent third party applications that utilize the data. It is hoped that this system will prove an invaluable tool for SNP and genotype based research and, in the future, will be extended beyond its present intentions.