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Title: Quality of self-selected diets of non-obese participants in a randomized controlled trial of caloric restriction (CR): the CALERIE study

Author
item BALES, CONNIE - DUKE UNIVERSITY MED CTR
item MCCRORY, M - TUFTS UNIVERSITY
item ZHENG, J - WASHINGTON UNIVERSITY
item CHAMPAGNE, C - PENNINGTON BIOMED CTR
item GILHOOLY, C - TUFTS UNIVERSITY
item HANNAH, J - NIA
item RACETTE, S - WASHINGTON UNIVERSITY
item MARTIN, C - PENNINGTON BIOMED CTR
item OBERT, K - WASHINGTON UNIVERSITY
item DAS, S - TUFTS UNIVERSITY
item DELANY, J - PENNINGTON BIOMED CTR
item MANDEL, S - WASHINGTON UNIVERSITY
item ROCHON, J - DUKE CLIN RES INST
item ROBERTS, S - TUFTS UNIVERSITY
item SCHECHTMAN, K - WASHINGTON UNIVERSITY
item Bogle, Margaret

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 3/30/2007
Publication Date: 4/30/2007
Citation: Bales, C.W., McCrory, M., Zheng, J., Champagne, C., Gilhooly, C., Hannah, J., Racette, S., Martin, C., Obert, K., Das, S., Delany, J., Mandel, S., Rochon, J., Roberts, S., Schechtman, K., Bogle, M.L. 2007. Quality of self-selected diets of non-obese participants in a randomized controlled trial of caloric restriction (CR): The CALERIE study [abstract]. Journal of Federation of American Societies for Experimental Biology. p. A155.

Interpretive Summary:

Technical Abstract: CR has been linked with improved health and longevity in scores of animal studies. The Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE) is a unique study of CR in non-obese humans. Phase 1 consisted of 3 single-site human CR studies at Tufts University (n=38), Washington University (n=28; Wash U), and the Pennington Biomedical Research Center (n=32; PBRC) (BMI 25-29.9 kg/m squared, mean age 35-55.4 yrs). The CR interventions were 10-30% CR for 6-12 mo. We examined reported self-selected intakes of fiber, protein, and 17 micronutrients from 7-d food diaries at baseline and 2 time points during CR. Nutritional adequacy was evaluated using the EAR out-point method. In all CR groups except Wash U (no change), the mean percentage of adequate nutrient intakes was higher by repeated measures mixed model ANOVA (p<0.039, Tufts; p<0.001, PBRC) during the CR period versus baseline. Intakes of 7 nutrients, including protein, were adequate at baseline and remained so. For most of the other nutrients, the percent of participants with adequate intakes was not associated with level or CR. We conclude: individuals who have been previously instructed on CR are able to self-select a CR diet that is nutritionally equal or superior to their baseline ad libitum diet.