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Title: The influence of immunogenomics on the innate immune response to avian influenza-comparison of toll-like receptor 7 and cytokine responses between chickens and ducks

Author
item Kapczynski, Darrell
item SMITH, A - INST ANIMAL HEALTH, UK
item PHILBIN, V - INST ANIMAL HEALTH, UK
item Liljebjelke, Karen
item Pantin Jackwood, Mary

Submitted to: American Association of Avian Pathologists
Publication Type: Abstract Only
Publication Acceptance Date: 6/30/2008
Publication Date: 7/19/2008
Citation: Kapczynski, D.R., Smith, A.L., Philbin, V., Liljebjelke, K.A., Pantin Jackwood, M.J. 2008. The influence of immunogenomics on the innate immune response to avian influenza-comparison of toll-like receptor 7 and cytokine responses between chickens and ducks [abstract]. In: Proceedings of the American Association of Avian Pathologists annual meeting, July 19-23, 2008, New Orleans, Louisiana. p. 85.

Interpretive Summary:

Technical Abstract: The early responses of the innate host defense are dedicated to the containment of pathogens, holding infections to a level that can be resolved by the ensuing acquired immune mechanisms. Toll-like receptor (TLR) family members are responsible for initiation of the innate immune response. In particular, TLR7 has been shown to respond to ssRNA viral genomes. To explore the differences in innate immune responses between chickens and ducks, sequence analysis of TLR7 was performed and compared with cytokine induction following highly pathogenic AI infection. Differences in the TLR7 gene and cytokine responses were observed between chickens and ducks.