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Title: UPDATE ON SLA GENES AND THEIR IMPACT ON IMMUNE AND DISEASE INTERACTIONS

Author
item Lunney, Joan
item HO, CHAK-SUM - UMMS, ANN ARBOR,MI
item Wysocki, Michal
item SMITH, DOUGLAS - UMMS, ANN ARBOR,MI

Submitted to: Animal Genetics International Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 6/24/2008
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: The swine major histocompatibility complex (MHC) or swine leukocyte antigen (SLA) complex is one of the most gene-dense regions in the swine genome. It consists of three major gene clusters, the SLA class I, class III and class II regions, that span ~1.1, 0.7 and 0.5 Mb, respectively, making the swine MHC the smallest among mammalian MHC so far examined and the only one known to span the centromere. There have been a considerable number of new SLA allele sequences and haplotypes designated by the ISAG SLA Nomenclature Committee. These have been used for the recent update of the Immuno Polymorphism Database-MHC (IPD-MHC) website (http://www.ebi.ac.uk/ipd/mhc/sla/) which serves as the repository for maintaining a list of all SLA recognized genes and their allelic sequences. We will review new methods for SLA haplotyping and summarize data on the expression of SLA proteins on cell subsets and their role in antigen presentation and regulating immune responses. This submission will summarize numerous studies that have probed the role of SLA genes in swine models of transplantation, xenotransplantation, cancer and allergy and in swine production traits and responses to infectious disease and vaccines.