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Title: Accuracy and Precision for EchoMRI-Infants™ Body Composition Analysis in Piglets

Author
item TAICHER, G - ECHO MEDICAL SYSTEMS
item KOVNER, I - ECHO MEDICAL SYSTEMS
item Mitchell, Alva

Submitted to: European Congress on Obesity
Publication Type: Abstract Only
Publication Acceptance Date: 2/12/2009
Publication Date: 5/16/2009
Citation: Taicher, G., Kovner, I., Mitchell, A.D. 2009. Accuracy and Precision for EchoMRI-Infants™ Body Composition Analysis in Piglets. 17th European Congress on Obesity. Poster ECO: PS 5-1.

Interpretive Summary: N/A

Technical Abstract: Body Composition Analysis is used to evaluate infant growth patterns, efficacy of nutritional and medical interventions, progression of chronic disease, and recovery from malnutrition. EchoMRI-Infants is a new Quantitative Magnetic Resonance (QMR) method to measure Total Body Fat, Lean Tissue Mass, Free Water Mass, and Total Body Water in infants. Success in using EchoMRI in subjects of different sizes (flies, mice, rats, birds, dogs, and humans) has been reported. We have determined precision and accuracy (with respect to chemical analysis) of EchoMRI-Infants in piglets. 25 piglets were measured for calibration using an EchoMRI-Infants device and then subjected to chemical analysis. Half a year later, a different set of 25 piglets were measured for validation using the same EchoMRI-Infants device and then subjected to chemical analysis. Every subject was measured 5 times in awake, anesthetized, and dead state. We evaluate precision in terms of Standard Deviations of repeated measurements. The Standard Deviation of difference between mean of repeated EchoMRI-Infants measurements and chemical analysis was taken as a measure of accuracy. The precision of Total Body Fat for the EchoMRI-Infants was 3.9, 17.6, and 5.0 g and the coefficient of correlation with chemical analysis was 0.999, 0.997, and 0.998 for anesthetized, awake, and dead piglets respectively. The accuracy of Total Body Fat for the EchoMRI-Infants was 25 g.