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ARS Home » Northeast Area » Boston, Massachusetts » Jean Mayer Human Nutrition Research Center On Aging » Research » Publications at this Location » Publication #236880
Title: Associations between body fat and vitamin K status in older women

Author
item KYLA M, SHEA - WAKE FOREST UNIVERSITY
item Saltzman, Edward
item GUNDBERG, CAREN - YALE UNIVERSITY
item WADDELL, CATHERINE - TUFTS UNIVERSITY
item BENNETT, GRACE - TUFTS UNIVERSITY
item Booth, Sarah

Submitted to: Journal of Federation of American Societies for Experimental Biology
Publication Type: Abstract Only
Publication Acceptance Date: 11/5/2008
Publication Date: 4/28/2009
Citation: Kyla M, S., Saltzman, E., Gundberg, C., Waddell, C., Bennett, G., Booth, S.L. 2009. Associations between body fat and vitamin K status in older women. Journal of Federation of American Societies for Experimental Biology. Abstract No. 566.3.

Interpretive Summary:

Technical Abstract: Fat soluble nutrients are stored in fat tissue. Yet, the association between body fat and vitamin K status is not clear. We examined associations between % body fat (%BF) and 3 circulating measures of vitamin K status [plasma phylloquinone (plasma K1), uncarboxylated prothrombin (PIVKA), uncarboxylated osteocalcin (%ucOC)] cross-sectionally in 262 women (60-80 yrs) using analysis of covariance adjusted for age, vitamin K intake, triglycerides, and smoking. Higher %BF was associated with lower plasma K1 (p-trend<0.01) and higher PIVKA (p-trend<0.01), both indicative of lower vitamin K status. There was a non-significant trend, but %ucOC did not differ across %BF tertiles (p=0.08). Linear regression was then used to assess the association between plasma K1 and the functional measures of PIVKA and %ucOC (as outcomes) in the separate %BF tertiles. The strength of the inverse association between plasma K1 and PIVKA increased across tertiles: unstd beta T1:-0.33(p=0.08), T2:-0.45 (p=0.02), and T3:-0.51(p=0.02), while the association between plasma K1 and %ucOC was weaker and non-significant among women in the highest %BF tertile: unstd beta T1:-9.9(p=0.01), T2:-18.9(p<0.01), and T3:-3.0(p=0.50). Further studies are needed to elucidate the meaning of the associations between body fat and the measures of vitamin K status. Research support: NIA A914759 & USDA ARS (cooperative agreement 58-1950-7-707)