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Title: High Resolution QTL Map Of Body Conformation Traits From Genome-Wide Association Analysis In Contemporary U.S. Holstein Cows

Author
item Wiggans, George
item MA, LI - University Of Minnesota
item Sonstegard, Tad
item Cole, John
item CROOKER, B - University Of Minnesota
item Van Tassell, Curtis - Curt
item YANG, J - University Of Minnesota
item MATUKUMALLI, L - US Department Of Agriculture (USDA)
item DA, Y - University Of Minnesota

Submitted to: Plant and Animal Genome Conference Proceedings
Publication Type: Abstract Only
Publication Acceptance Date: 12/31/2009
Publication Date: 1/9/2010
Citation: Wiggans, G.R., Ma, L., Sonstegard, T.S., Cole, J.B., Crooker, B.A., Van Tassell, C.P., Yang, J., Matukumalli, L.K., Da, Y. 2010. High Resolution QTL Map Of Body Conformation Traits From Genome-Wide Association Analysis In Contemporary U.S. Holstein Cows. Plant and Animal Genome Conference Proceedings. San Diego, Ca, Jan. 9-13, abstr. P547.

Interpretive Summary:

Technical Abstract: A QTL map of 1,005 SNP markers affecting 18 body conformation traits (top 100 effects per trait) was constructed based on a genome-wide association analysis of 1,654 contemporary U.S. Holstein cows genotyped with the BovineSNP50 (45,878 SNPs). The top 100 effects for each trait explained 38-56% of the phenotypic variation. The 1,005 SNPs were distributed across all chromosomes but several chromosomes had high concentrations of SNP effects, including BTA11 for stature, body depth, rear udder height (RUH), rear legs rear-view (RLR), teat length (TL) and final score (FS); BTA10 for dairy form, RUH and FS; BTA17 for TL; BTA26 for feet and legs, foot angle and TL; and BTAX for strength, rump width and RLR; BTA6 for front teat placement; BTA7 and BTA19 for udder cleft, and BTA1, BTA18 and BTAX for rear legs side-view. BTA11 had the highest concentration of SNP effects and most of those effects were in a 10 Mb region. BTA5 had the 4th largest number of SNP effects but few were among the top 20 effects. Of the 1,005 SNP markers, 366 (36.4%) were in 297 genes. The renin (REN) gene of BTA16 was highly significant for 12 traits. Genes with or near an SNP affecting 7-11 traits include: LOC515732, GPM6B and LOC100140016 of BTAX; MGMT of BTA26; GPRC5C and SRP68 of BTA19; LETM1 of BTA6; CRTC1 of BTA7; BTBD11 of BTA5; RAB15 of BTA10; and OSR1 and LOC521982 of BTA11. These results assist in understanding genetic factors underlying body conformation traits in dairy cattle.