Author
|
Submitted to: University of Maryland Experiment Station Report
Publication Type: Experiment Station Publication Acceptance Date: 1/7/2011 Publication Date: 1/17/2011 Citation: Lunney, J.K. 2011. BARC 2010 Annual Report for NRSP-8 National Animal Genome Research Program (NAGRP). University of Maryland Experiment Station Report. Available: http://www.lgu.umd.edu/_lgu_v2/pages. Interpretive Summary: Technical Abstract: BARC 2010 has contributed to the National Animal Genome Research Program (NAGRP). The NRSP8 NAGRP’s objectives are 1) Enhance and integrate genetic and physical maps of agriculturally important animals for cross species comparisons and sequence annotation; 2) Facilitate integration of genomic, transcriptional, proteomic and metabolomic approaches toward better understanding of biological mechanisms underlying economically important traits; and 3) BARC 2010 has contributed to the National Animal Genome Research Program (NAGRP). The NRSP8 NAGRP’s objectives are 1) Enhance and integrate genetic and physical maps of agriculturally important animals for cross species comparisons and sequence annotation; 2) Facilitate integration of genomic, transcriptional, proteomic and metabolomic approaches toward better understanding of biological mechanisms underlying economically important traits; and 3) Facilitate and implement bioinformatic tools to extract, analyze, store and disseminate information. For Obj.1 BARC has collaborated on updates on the nomenclature for the swine leukocyte antigen (SLA) complex. They have optimized methods for identifying SLA class I and II alleles for understaning gentic resistance to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) infection. For Obj. 2 BARC used the Pigoligoarray (www.pigoligoarray.org) to assess swine responses to PRRSV infection. They probed immune regulatory and protective pathways activated in samples from swine infected with virulent PRRS virus and compare them to samples from vaccinated pigs. BARC has co-led the PRRS Host Genomic Consortium (PHGC) studies of blood samples collected from PRRSV infected PHGC pigs. For Obj.3 BARC has worked to develop and assure secure data collection for the PHGC by its comprehensive PHGC database http://www.animalgenome.org/lunney/index.php. This information will serve as a basis for determining critical genetic effects on pig genetics and genomic controls of infectious disease and vaccine responses. It is already being tested in PRRSV responses. |
