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Title: Parenteral lipid fatty acid composition directly determines the fatty acid composition of red blood cell and brain lipids in preterm pigs

Author
item STOLL, BARBARA - Children'S Nutrition Research Center (CNRC)
item VLAARDINGERBROEK, HESTER - Erasmus Medical Center
item BENIGHT, NANCY - Children'S Nutrition Research Center (CNRC)
item OLUTOYE, OLUYINKA - Baylor College Of Medicine
item VAN GOUDOEVER, JOHANNES - Children'S Nutrition Research Center (CNRC)
item HEIRD, WILLIAM - Children'S Nutrition Research Center (CNRC)
item Burrin, Douglas - Doug

Submitted to: Pediatric Academic Society
Publication Type: Abstract Only
Publication Acceptance Date: 4/14/2011
Publication Date: 4/30/2011
Citation: Stoll, B., Vlaardingerbroek, H., Benight, N.M., Olutoye, O., Van Goudoever, J., Heird, W., Burrin, D.G. 2011. Parenteral lipid fatty acid composition directly determines the fatty acid composition of red blood cell and brain lipids in preterm pigs [abstract]. In: Proceedings of the 2011 Annual Conference of the Pediatric Academic Society and the Asian Society for Pediatric Research. Session: Neonatal fetal nutrition and metabolism II, April 30-May 3, 2011, Denver, Colorado. 3670.5.

Interpretive Summary:

Technical Abstract: Studies in enterally-fed infants have shown a positive effect of n-3 long-chain polyunsaturated fatty acid (LCPUFA) supplementatin on neurodevelopment. The effect of n-3 LCPUFA in fish oil-based parenteral (PN) lipid emulsions on neuronal tissues of PN-fed preterm infants is unknown. The objective of this study was to test whether different PN lipid emulsions directly modify the tissue composition and metabolism of lipids in preterm pigs. Preterm pigs bearing venous and arterial catheters received 1 of 4 treatments (7-14 pigs/group): PN + soybean oil (Intralipid, IL), PN + fish (Omegaven, OV), PN + oil mixture w/soybean (30 percent)-coconut (30 percent)-olive (25 percent)-fish (15 percent) (SMOFlipid, SL), milk formula fed enterally (EN). On d 11, pigs were subjected to (13)C-palmitate oxidation and whole-body respiratory calorimetry measures; on d 14 blood and tissues were collected for analysis of lipid composition. Heat and (13)CO2 production from (13)C palmitate, respiratory quotient (RQ), serum cholesterol, triglycerides, and VLDL were not different between PN groups. However, RQ was higher in OV than EN. The intake and tissue concentration of essential LCPUFA, including (18:2)n-6 and (18:3)n-3, were higher in IL vx either OV or SL. The intake and tissue concentrations of the LCPUFA, including (20:5)n-3 and (22:6)n-3, were higher in OV and SL vs IL groups. The concentrations of these latter n-3 LCPUFA tend to be higher in OV than in the SL group.) In conclusion, the chronic parenteral infusion of fish oil-containing lipid emulsions results in higher proportions of n-3 LCPUFA in blood, liver and brain of preterm pigs. The enrichment of tissue with n-3 LCPUFA may have benefical metabolic and functional actions in preterm infants.