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ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #270866
Title: Genome sequence of Haemophilus parasuis strain 29755

Author
item Mullins, Michael
item Register, Karen
item Bayles, Darrell
item DYER, DAVID - University Of Oklahoma
item KUEHN, JOANNA - Iowa State University
item PHILLIPS, GREGORY - Iowa State University

Submitted to: Standards in Genomic Sciences
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/23/2011
Publication Date: 10/15/2011
Citation: Mullins, M.A., Register, K.B., Bayles, D.O., Dyer, D.W., Kuehn, J.S., Phillips, G.J. 2011. Genome sequence of Haemophilus parasuis strain 29755. Standards in Genomic Sciences. 5(1):61-68.

Interpretive Summary: Haemophilus parasuis, the bacterium responsible for Glasser's disease, is a pathogen of significant concern in modern high-health swine production systems. Traditional scientific approaches have so far failed to reveal the identity or function of its virulence factors. This report describes the features of the genome sequence from H. parasuis strain 29755, a virulent isolate long used in the study of Glasser's disease. The genome sequence of strain 29755 will aid researchers in their efforts to understand the genetic basis for pathogenesis of H. parasuis. These data provided the first publicly available genome sequence for this bacterium.

Technical Abstract: Haemophilus parasuis is a member of the family Pasteurellaceae and is the etiologic agent of Glasser's disease in pigs, a systemic syndrome associated with only a subset of isolates. The genetic basis for virulence and systemic spread of particular H. parasuis isolates is currently unknown. Strain 29755 is an invasive isolate that has long been used in the study of Glasser's disease. Accordingly, elucidation of the genome sequence of strain 29755 will aid researchers in their efforts to understand the pathogenesis of H. parasuis. Here we describe the features of the 2,224,137 bp draft genome sequence of strain 29755 generated from 454-FLX pyrosequencing. These data provided the first publicly available genome sequence for this bacterium.