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ARS Home » Plains Area » Manhattan, Kansas » Center for Grain and Animal Health Research » Hard Winter Wheat Genetics Research » Research » Publications at this Location » Publication #291562
Title: A heterozygous moth genome provides insights into herbivory and detoxification

Author
item YOU, MINSHENG - Fujian Agricultural & Forestry University
item YUE, ZHEN - Beijing Genome Institute
item HE, WEIYI - Fujian Agricultural & Forestry University
item YANG, XINHUA - Beijing Genome Institute
item YANG, GUANG - Fujian Agricultural & Forestry University
item XIE, MIAO - Fujian Agricultural & Forestry University
item ZHAN, DONGLIANG - Beijing Genome Institute
item BAXTER, SIMON - University Of Cambridge
item VASSEUR, LIETTE - Fujian Agricultural & Forestry University
item GURR, GEOFF - Fujian Agricultural & Forestry University
item DOUGLAS, CARL - Fujian Agricultural & Forestry University
item BAI, JIANLIN - Fujian Agricultural & Forestry University
item WANG, PING - Cornell University
item CUI, KAI - Fujian Agricultural & Forestry University
item HUANG, SHIGUO - Fujian Agricultural & Forestry University
item LI, XIANCHUN - University Of Arizona
item ZHOU, QING - Beijing Genome Institute
item WU, ZHANGYAN - Beijing Genome Institute
item CHEN, QILIN - Beijing Genome Institute
item LIU, CHUNHUI - Fujian Agricultural & Forestry University
item WANG, BO - Beijing Genome Institute
item LI, XIAOJING - Fujian Agricultural & Forestry University
item XU, XUIFENG - Fujian Agricultural & Forestry University
item LU, CHANGXIN - Beijing Genome Institute
item HU, MIN - Beijing Genome Institute
item DAVEY, JOHN - Fujian Agricultural & Forestry University
item SMITH, SANDY - Fujian Agricultural & Forestry University
item Chen, Ming-Shun
item XIA, XIAOFENG - Fujian Agricultural & Forestry University
item TANG, WEIQI - Fujian Agricultural & Forestry University
item KE, FUSHI - Fujian Agricultural & Forestry University
item ZHENG, DANDAN - Fujian Agricultural & Forestry University
item HU, YULAN - Fujian Agricultural & Forestry University
item SONG, FENGQIN - Fujian Agricultural & Forestry University
item YOU, YANCHUN - Fujian Agricultural & Forestry University
item MA, XIAOLI - Fujian Agricultural & Forestry University
item PENG, LU - Fujian Agricultural & Forestry University
item ZHENG, YUNKAI - Fujian Agricultural & Forestry University
item LIANG, YONG - Fujian Agricultural & Forestry University
item CHEN, YAQIONG - Fujian Agricultural & Forestry University
item YU, LIYING - Fujian Agricultural & Forestry University
item ZHANG, YOUNAN - Fujian Agricultural & Forestry University
item LIU, YUANYUAN - University Of British Columbia
item LI, GUOQING - Beijing Genome Institute
item FANG, LIN - Beijing Genome Institute
item LI, JINGXIANG - Beijing Genome Institute
item ZHOU, XIN - Beijing Genome Institute
item LOU, YADAN - Beijing Genome Institute
item GOU, CAIYUN - Beijing Genome Institute
item WANG, JUNYI - Beijing Genome Institute
item WANG, JIAN - Beijing Genome Institute
item YANG, HUANMING - Beijing Genome Institute
item WANG, JUN - Beijing Genome Institute

Submitted to: Nature Genetics
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/12/2012
Publication Date: 1/13/2013
Publication URL: http://www.nature.com/ng/journal/v45/n2/abs/ng.2524.html
Citation: You, M., Yue, Z., He, W., Yang, X., Yang, G., Xie, M., Zhan, D., Baxter, S.W., Vasseur, L., Gurr, G.M., Douglas, C.J., Bai, J., Wang, P., Cui, K., Huang, S., Li, X., Zhou, Q., Wu, Z., Chen, Q., Liu, C., Wang, B., Li, X., Xu, X., Lu, C., Hu, M., Davey, J.W., Smith, S.M., Chen, M., Xia, X., Tang, W., Ke, F., Zheng, D., Hu, Y., Song, F., You, Y., Ma, X., Peng, L., Zheng, Y., Liang, Y., Chen, Y., Yu, L., Zhang, Y., Liu, Y., Li, G., Fang, L., Li, J., Zhou, X., Lou, Y., Gou, C., Wang, J., Wang, J., Yang, H., Wang, J. 2013. A heterozygous moth genome provides insights into herbivory and detoxification. Nature Genetics. doi:10.1038/ng.2524.

Interpretive Summary: The diamondback moth is a serious pest of vegetables worldwide. The insect feeds on plants that produce glucosinolates, which are toxic to other types of insects. The diamondback moth is also highly capable of developing new strains that are resistant to various synthetic chemical pesticides. This study sequenced and analyzed the whole genome of the diamondback moth. The genome is highly heterogeneous and contains 18,071 protein-coding and 1,412 unique genes. Several gene families associated with perception and the detoxification of plant defense compounds are expanded in comparison with those of other insect species. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to be involved in the development of insecticide resistance. This work revealed the genetic and molecular bases for an herbivore to adapt to toxic chemicals of host plants.

Technical Abstract: How an insect evolves to become a successful herbivore is of profound biological and practical importance. Herbivores are often adapted to feed on a specific group of evolutionarily and biochemically related host plants, but the genetic and molecular bases for adaptation to plant defense compounds remain poorly understood. We report the first whole-genome sequence of a basal lepidopteran species, Plutella xylostella, which contains 18,071 protein-coding and 1,412 unique genes with an expansion of gene families associated with perception and the detoxification of plant defense compounds. A recent expansion of retrotransposons near detoxification-related genes and a wider system used in the metabolism of plant defense compounds are shown to also be involved in the development of insecticide resistance. This work shows the genetic and molecular bases for the evolutionary success of this worldwide herbivore and offers wider insights into insect adaptation to plant feeding, as well as opening avenues for more sustainable pest management.