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ARS Home » Plains Area » Fargo, North Dakota » Edward T. Schafer Agricultural Research Center » Food Animal Metabolism Research » Research » Publications at this Location » Publication #291762
Title: Application of kidney inhibition swab tests to evaluate penicillin-G residues in sow tissues and body fluids following intramuscular injection

Author
item Shelver, Weilin
item Lupton, Sara
item NEWMAN, DAVID - North Dakota State University
item LARSEN, STEVEN - National Pork Board
item Smith, David

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 7/2/2013
Publication Date: 8/26/2013
Citation: Shelver, W.L., Lupton, S.J., Newman, D.J., Larsen, S., Smith, D.J. 2013. Application of kidney inhibition swab tests to evaluate penicillin-G residues in sow tissues and body fluids following intramuscular injection [abstract]. Association of Analytical Communities Annual Meeting & Exposition. Poster No. P-M-048.

Interpretive Summary:

Technical Abstract: Kidney inhibition swab (KIS) tests, recently adapted by the US FSIS for antibiotics on-site screening, were employed to evaluate the depletion of penicillin-G residues from kidney, liver, muscle, serum, and urine of sows after intramuscular (IM) penicillin-G procaine administration. Sows (n=130; 227.0 +/- 30.8 kg) were provided daily IM doses of penicillin-G (33,000 U/kg bw; 5x the label dose) for 3 consecutive days using 3 separate administration patterns and six sows per treatment. Sows were slaughtered after 5, 10, 15, 20, 25, 32, or 39 day withdrawal periods. Residues depleted most rapidly from liver and skeletal muscle and the slowest from kidney and urine. Kidney was the most appropriate target tissue for detecting penicillin-G residues in carcasses, with two positive results after a 39-day withdrawal period. These data support a 15-day withdrawal period for penicillin-G treated sows though kidneys may need to be excluded from human consumption.