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ARS Home » Pacific West Area » Logan, Utah » Poisonous Plant Research » Research » Publications at this Location » Publication #299109
Title: Induction and transfer of resistance to poisoning by Amorimia (Macagnia) septentrionalis in goats

Author
item DUARTE, AMELIA - Federal University Of Campina Grande
item MEDEIROS, ROSANE - Federal University Of Campina Grande
item CARVALHO, FABRICIO - Federal University Of Campina Grande
item Lee, Stephen
item Cook, Daniel
item Pfister, James
item COSTA, VALERIA - Federal University Of Campina Grande
item RIET-CORREA, FRANKLIN - Federal University Of Campina Grande

Submitted to: Journal of Applied Toxicology
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/27/2012
Publication Date: 2/1/2014
Citation: Duarte, A.L., Medeiros, R.M., Carvalho, F.K., Lee, S.T., Cook, D., Pfister, J.A., Costa, V.M., Riet-Correa, F. 2014. Induction and transfer of resistance to poisoning by Amorimia (Macagnia) septentrionalis in goats. Journal of Applied Toxicology. 34(2):220-223.

Interpretive Summary: Amorimia septentrionalis contains sodium monofluoroactetate (MFA) and can cause heart failure in ruminants when ingested in toxic doses. In this study, we demonstrate that resistance to poisoning by A. septentrionalis can be improved in goats by the repeated administration of non-toxic doses of A. septentrionalis. We also show that resistance to poisoning by A. septentrionalis can also be achieved by the transfer of ruminal content from goats previously conditioned to be resistant to naïve goats. These methods of improving resistance require further study, but appear to provide potential management solutions to mitigate toxicity problems from A. septentrionalis, and perhaps other plant species containing MFA.

Technical Abstract: Amorimia septentrionalis contains sodium monofluoroactetate (MFA) and can cause acute heart failure in ruminants when ingested in toxic doses. In this study, we demonstrate that resistance to poisoning by A. septentrionalis can be improved in goats by the repeated administration of non-toxic doses of A. septentrionalis. We also show that resistance to poisoning by A. septentrionalis can also be achieved by the transfaunation of ruminal content from goats previously conditioned to be resistant to naïve goats. These methods of improving resistance require further study, but appear to provide potential management solutions to mitigate toxicity problems from A. septentrionalis, and perhaps other plant species containing MFA.