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Title: New secondary metabolites isolated from dondonae viscosa

Author
item MOSTAFA, AHMAD - University Of Mississippi
item EL-HELA, ATEF - University Of Mississippi
item MOHAMMAD, ABD-ELSALAM - University Of Mississippi
item JACOB, MELISSA - University Of Mississippi
item CUTLER, STEPHEN - University Of Mississippi
item ROSS, SAMIR - University Of Mississippi

Submitted to: Phytochemistry Letters
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 12/11/2013
Publication Date: 1/9/2014
Citation: Mostafa, A.E., El-Hela, A.A., Mohammad, A.I., Jacob, M., Cutler, S., Ross, S. 2014. New secondary metabolites isolated from dondonae viscosa. Phytochemistry Letters. 8:10-15.

Interpretive Summary: In our researches to discover new active metabolites, Dodonaea viscosa Linn. from Egypt was selected for this work. The bioassay guided fractionation of its ethanolic extract of the aerial parts, resulted in the isolation and identification of three new compounds, including two new clerodane diterpenoids and a new myo-inositol derivative, along with nine known compounds. All isolated compounds were evaluated for their antibacterial, antifungal, antimalarial as well as antileishmanial activities. One of the isolated compounds exhibited good antifungal activity against Cryptococcus neoformans with an IC50 value of 6.11 µg/ml. While another two compounds showed moderate antileishmanial activity against Leishmania donovani with IC50 values of 16.6 and 19.06 µg/ml.

Technical Abstract: Bioassay guided fractionation and chemical investigation of the ethanolic extract of the aerial parts of Dodonaea viscosa Linn. from Egypt, resulted in the isolation and identification of three new compounds, including two new clerodane diterpenoids and a new myo-inositol derivative, along with nine known compounds. The structures of the isolated compounds were elucidated using 1D and 2D NMR experiments, HRESIMS, and comparison with literature data. All isolated compounds were evaluated for their antibacterial, antifungal, antimalarial as well as antileishmanial activities. Compound (5) exhibited good antifungal activity against Cryptococcus neoformans with an IC50 value of 6.11 µg/ml. Compounds (10, 12) showed moderate antileishmanial activity against Leishmania donovani with IC50 values of 16.6 and 19.06 µg/ml, respectively.