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Title: Pharmacological activities of cilantro’s aliphatic Aldehydes against leishmania donovani

Author
item DONEGA, MATEUS - Universidad De Sao Paulo
item MELLO, SIMONE - University Of Mississippi
item MORAES, RITA - University Of Mississippi
item JAIN, SURENDRA - University Of Mississippi
item TEKWANI, BABU - University Of Mississippi
item Cantrell, Charles

Submitted to: Planta Medica
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/18/2014
Publication Date: 10/23/2014
Publication URL: http://handle.nal.usda.gov/10113/62279
Citation: Donega, M., Mello, S.C., Moraes, R.M., Jain, S.K., Tekwani, B., Cantrell, C.L. 2014. Pharmacological activities of cilantro’s aliphatic Aldehydes against leishmania donovani. Planta Medica. 80:1706-1711.

Interpretive Summary: Leishmaniasis is a chronic infectious disease caused by different Leishmania species. Global occurrences of this disease are primarily limited to tropical and subtropical regions. Treatments are available; however, patients complain of side effects. Different species of plants have been screened as a potential source of new drugs against leishmaniasis. In this study, we investigated the antileishmanial activity of cilantro essential oil, and its main aliphatic aldehyde components. Cilantro’s essential oil achieved 98% inhibition of Leishmani donovani promastigotes. The aliphatic aldehydes, are effective inhibitors of in vitro cultures of L. donovani promastigotes and axenic amastigotes. The results showed that essential oil of C. sativum leaves and its major compounds may represent a valuable source of new drugs against Leishmaniasis.

Technical Abstract: Leishmaniasis is a chronic infectious disease caused by different Leishmania species. Global occurrences of this disease are primarily limited to tropical and subtropical regions. Treatments are available; however, patients complain of side effects. Different species of plants have been screened as a potential source of new drugs against leishmaniasis. In this study, we investigated the antileishmanial activity of cilantro essential oil, and its main components: (E)-2-undecenal, (E)-2-decenal, (E)-2-dodecenal, decanal, dodecanal and n-tetradecanal. Cilantro’s essential oil achieved 98% inhibition of Leishmani donovani promastigotes. The aliphatic aldehydes (E)-2-undecenal, (E)-2-decenal and (E)-2-dodecenal, are effective inhibitors of in vitro cultures of L. donovani promastigotes and axenic amastigotes. These cilantro compounds showed no toxicity against L. donovani in THP1 macrophages cultures.