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ARS Home » Plains Area » Manhattan, Kansas » Center for Grain and Animal Health Research » ABADRU » Research » Publications at this Location » Publication #303140
Title: Comparison of Rift Valley fever virus and MP-12 replication in domestic livestock and North American wildlife cell lines.

Author
item Gaudreault, Natasha
item INDRAN, SABARISH - Kansas State University
item Bryant, Paul
item RICHT, JUERGEN - Kansas State University
item Wilson, William - Bill

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 6/13/2015
Publication Date: N/A
Citation: N/A

Interpretive Summary: Rift Valley fever virus (RVFV) is a mosquito-transmitted pathogen that primarily affects livestock, but can also cause mild to fatal disease in humans. Currently, there is no approved vaccine for use in the United States (US). Domestic goats, sheep and cattle are susceptible hosts for RVFV and several competent vectors exist in North America. However, it remains unknown whether native wildlife could play a role in potentiating this disease if it were introduced to the US. This study evaluates the ability of a variety of cell lines from wildlife found throughout North America to support RVFV infection. The results suggest that RVFV could potentially replicate not only in domestic livestock, but native deer species and possibly a wide range of non-ruminant animals. This work serves as a model system to guide and support future animal studies for risk assessment of this foreign zoonotic disease.

Technical Abstract: Rift Valley fever virus (RVFV) is a mosquito-transmitted pathogen that primarily affects livestock, but can also cause mild to fatal disease in humans. Currently, there is no approved vaccine for use in the United States if it were introduced. Domestic goats, sheep and cattle are susceptible hosts for RVFV and several competent vectors exist in North America. However, it remains unknown whether native wildlife could act as potential amplifying hosts or reservoirs for this disease. In this study, the susceptibility and permissiveness of a variety of cell lines from wildlife found throughout North America to RVFV were evaluated. The results suggest that RVFV could potentially replicate not only in domestic livestock, but native deer species and possibly a wide range of non-ruminant animals. This work serves as a model system to guide and support future in vivo studies for risk assessment of this foreign zoonotic disease.