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Title: Angus sattle at high altitude: Genetic relationships and initial genome-wide association analyses of pulmonary arterial pressure

Author
item COCKRUM, R - Virginia Polytechnic Institution & State University
item ZENG, X - Colorado State University
item BERGE, N - Colorado State University
item NEARY, J - Colorado State University
item GARRY, F - Colorado State University
item HOLT, T - Colorado State University
item Blackburn, Harvey
item THOMAS, T - Colorado State University
item SPEIDEL, S - Colorado State University
item GARRICK, D - Iowa State University
item ENNS, R - Colorado State University
item THOMAS, M - Colorado State University

Submitted to: Symposium Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 4/4/2014
Publication Date: 4/4/2014
Citation: Cockrum, R.R., Zeng, Berge, N.F., Neary, J.M., Garry, F.B., Holt, T., Blackburn, H.D., Thomas, T., Speidel, S.E., Garrick, D.J., Enns, R.M., Thomas, M.G. 2014. Angus sattle at high altitude: Genetic relationships and initial genome-wide association analyses of pulmonary arterial pressure. Symposium Proceedings. World Congress of Genetics Applied to Livestock Production Vancouver, BC, Canada, Aug 17-22, 2014.

Interpretive Summary:

Technical Abstract: Records from yearling Angus (n = 10,647) cattle from elevation 2,340 m were used in genetic analysis of pulmonary arterial pressure (PAP). Bulls were developed within a grain-supplemented performance test, whereas heifers and steers were grazed. The BovineSNP50 Beadchip was used to genotype a subset of cattle (n = 1,690). Bulls had greater (P<0.001) yearling PAP values as compared to steers and heifers. Heritability ranged from 0.20 in heifers and steers to 0.31 ± 0.15 in bulls. Moderate positive genetic correlations were observed in PAP measures with heifers and bulls (0.64 ± 0.14) and steers (0.74 ± 0.37). Genomewide association analyses using multi-locus mixed model and Bayesian approaches revealed several QTL for PAP; however, no concordant SNP (P<0.001) were observed among males and females. Therefore, results suggest that PAP appears to be a polygenic trait influenced by sex and (or) growth.