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ARS Home » Plains Area » Grand Forks, North Dakota » Grand Forks Human Nutrition Research Center » Healthy Body Weight Research » Research » Publications at this Location » Publication #306462
Title: A diet with 3% of energy from a mixture of Omega-3 fatty acids significantly increases in vivo lipid peroxidation in postmenopausal women

Author
item AINSLIE-WALDMAN, CHERYL - University Of Minnesota
item YOUNG, LINDSAY - University Of Minnesota
item CHEN, CHI - University Of Minnesota
item KURZER, MINDY - University Of Minnesota
item Raatz, Susan
item CSALLANY, SAARI - University Of Minnesota

Submitted to: Food and Nutrition Sciences
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/16/2016
Publication Date: 10/20/2016
Publication URL: http://handle.nal.usda.gov/10113/63304
Citation: Ainslie-Waldman, C.E., Young, L.R., Chen, C., Kurzer, M.S., Raatz, S.K., Csallany, S.A. 2016. Moderate consumption of Omega-3 fatty acids significantly increases in vivo lipid peroxidation in postmenopausal women. Food and Nutrition Sciences. 7:1099-1111.

Interpretive Summary: Dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) are recommended by public health organizations to reduce the risk of disease. However, n-3 PUFA are susceptible to an increase in lipid peroxidation in the human body. As part of a crossover dietary intervention study of a diet (20% of energy from fat) with or without an additional 3% of energy from n-3 PUFA, we measured total in vivo lipid peroxidation in healthy postmenopausal women (n=15). Our results indicated that the diet with 3% of energy from n-3 PUFA significantly increased the urinary concentrations compounds produced via lipid compared to the diet with less than 1% of energy from n-3 PUFA. These results demonstrate that an increase in 3% of energy from dietary n-3 PUFA increases in vivo lipid peroxidation.

Technical Abstract: Dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) are recommended by public health organizations to reduce the risk of disease. However, n-3 PUFA are susceptible to an increase in lipid peroxidation in the human body. As part of a crossover dietary intervention study of a diet (20% of energy from fat) with or without an additional 3% of energy from n-3 PUFA, we measured total in vivo lipid peroxidation in healthy postmenopausal women (n=15). Our results indicated that the diet with 3% of energy from n-3 PUFA significantly increased the urinary concentrations compounds produced via lipid compared to the diet with less than 1% of energy from n-3 PUFA. These results demonstrate that an increase in 3% of energy from dietary n-3 PUFA increases in vivo lipid peroxidation.