Author
REN, X - Harbin Veterinary Research Institute | |
DONG, B - Harbin Veterinary Research Institute | |
Zarlenga, Dante |
Submitted to: Journal of Immunology
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 3/23/2014 Publication Date: 6/5/2014 Publication URL: http://handle.nal.usda.gov/10113/59391 Citation: Dong, B., Zarlenga, D.S., Ren, X., 2014. An overview of live attenuated recombinant pseudorabies viruses for use as novel vaccines. Journal of Immunology, 2014. 1-10. Article ID 824630, DOI:10.1155/2014/824630. Interpretive Summary: Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. In cell culture, PRV has many non-essential genes which can be replaced with genes encoding foreign antigens without harming virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controling viral infections in animals. Technical Abstract: Pseudorabies virus (PRV) is a double-stranded, DNA-based swine virus with a genome approximating 150 kb in size. In cell culture, PRV has many non-essential genes which can be replaced with genes encoding heterologous antigens but without deleterious effects on virus propagation. Recombinant PRVs expressing both native and foreign antigens are able to stimulate immune responses. In this paper, we review the current status of live attenuated recombinant PRVs and live PRV-based vector vaccines with potential for controling viral infections in animals. |