Author
METWALY, AHMED - University Of Mississippi | |
FRONCZEK, FRANK - University Of Mississippi | |
MA, GUOYI - University Of Mississippi | |
KADRY, HAZEM - University Of Mississippi | |
EL-HELA, ATEF - University Of Mississippi | |
MOHAMMAD, ABD-ELSALAM - University Of Mississippi | |
CUTLER, STEPHEN - University Of Mississippi | |
ROSS, SAMIR - University Of Mississippi |
Submitted to: Tetrahedron Letters
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 4/23/2014 Publication Date: 5/2/2014 Citation: Metwaly, A.M., Fronczek, F.R., Ma, G., Kadry, H.A., El-Hela, A.A., Mohammad, A.I., Cutler, S.J., Ross, S. 2014. Antileukemic alpha-pyrone derivatives from the endophytic fungus Alternaria phragmospora. Tetrahedron Letters. 55:3478-3481. Interpretive Summary: Four new and two known alpha-pyrone derivatives have been isolated from Alternaria phragmospora, an endophytic fungus from Vinca rosea, leaves. The isolated compounds were chemically identified by spectroscopic analyses. Two compounds showed moderate antileukemic activities against HL60 cells with IC50 values of 2.2 and 0.9 lM and against K562 cells with IC50 values of 4.5 and 1.5 lM, respectively. Technical Abstract: Four new (1–4) and two known (5 and 6)a-pyrone derivatives have been isolated from Alternaria phragmospora, an endophytic fungus from Vinca rosea, leaves. The isolated compounds were chemically identi'ed to be 5-butyl-4-methoxy-6-methyl-2H-pyran-2-one (2) 5-butyl-6-(hydroxymethyl)-4-methoxy-2H-pyran-2-one (2), 5-(1-hydroxybutyl)-4-methoxy-6-methyl-2H-pyran-2-one (3)4-methoxy-6- methyl-5-(3-oxobutyl)-2H-pyran-2-one (4),5-(2-hydroxyethyl)-4-methoxy-6-methyl-2H-pyran-2-one (5)and 5-[(2E)-but-2-en-1-yl]-4-methoxy-6-methyl-2H-pyran-2-one(6). Compounds 2 and 4 showed moderate antileukemic activities against HL60 cells with IC50 values of 2.2 and 0.9 lM and against K562 cells with IC50 values of 4.5 and 1.5 lM, respectively. |