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ARS Home » Northeast Area » Boston, Massachusetts » Research » Publications at this Location » Publication #307725
Title: Sedentary lifestyle and its relation to cardiovascular risk factors, insulin resistance and inflammatory profile

Author
item LEON-LATRE, MONTSERRAT - Instituto Aragone' S De Ciencias De La Salud
item MORENO-FRANCO, BELEN - Instituto Aragone' S De Ciencias De La Salud
item ANDRES-ESTEBAN, EVA - Hospital 12 De Octubre
item LEDESMA, MARTA - Instituto Aragone' S De Ciencias De La Salud
item LACLAUSTRA, MARTIN - National Center For Cardiovascular Research(CNIC)
item ALCALDE, VICTOR - General Motors
item PENALVO, JOSE - National Center For Cardiovascular Research(CNIC)
item ORDOVAS, JOSE - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item CASASNOVAS, JOSE - Instituto Aragone' S De Ciencias De La Salud

Submitted to: Revista Espanola De Cardiologia
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 10/4/2013
Publication Date: 6/1/2014
Citation: Leon-Latre, M., Moreno-Franco, B., Andres-Esteban, E.M., Ledesma, M., Laclaustra, M., Alcalde, V., Penalvo, J.L., Ordovas, J.M., Casasnovas, J.A. 2014. Sedentary lifestyle and its relation to cardiovascular risk factors, insulin resistance and inflammatory profile. Revista Espanola De Cardiologia. 67(6):449-455.

Interpretive Summary: In addition to unhealthy dietary habits, sedentary lifestyle represents a major risk factor for cardiovascular diseases, diabetes and chronic inflammation, all of them associated with decreased life expectancy and poor aging. Our objective was to analyze the association between sitting time (independent of overall physical activity) and biomarkers of insulin resistance and inflammation in a sample of healthy male workers (n=929). We collected information about sociodemographic, anthropometric, pharmacological and laboratory data. Information on sitting time and physical activity was assessed using a questionnaire. Our results show that the most sedentary individuals had higher body mass index, greater waist circumference, and higher systolic blood pressure. Likewise, they had a more blood lipid profile which tends to promote plaque formation, higher inflammation profile and insulin concentrations. In summary, among these workers, those who spend more time sitting show a worse inflammatory and insulin resistance profile independently of the habitual physical activity they performed.

Technical Abstract: The objective of this study is to analyze the association between sitting time and biomarkers of insulin resistance and inflammation in a sample of healthy male workers. A cross-sectional study was carried out in a sample of 929 volunteers belonging to the Aragon Workers' Health Study cohort. Sociodemographic, anthropometric, pharmacological and laboratory data were collected: lipids-total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, apolipoproteins A-1 and B-100, lipoprotein (a)-, insulin resistance-glucose, glycated hemoglobin, homeostasis model assessment of insulin resistance, insulin, and triglyceride/high-density lipoprotein cholesterol ratio-, and inflammatory profile-C-reactive protein and leukocytes. Information on sitting time and physical activity was assessed using a questionnaire. Sedentary behavior was analyzed in terms of prevalences and medians, according to tertiles, using a multivariate model (crude and adjusted linear regression) with biomarkers of inflammation and insulin resistance. The most sedentary individuals had higher body mass index, greater waist circumference, and higher systolic blood pressure, with a significant upward trend in each tertile. Likewise, they had a worse lipid profile with a higher C-reactive protein level, homeostasis model assessment of insulin resistance index, triglyceride/high-density lipoprotein cholesterol ratio, and insulin concentration. In the multivariate analysis, we observed a significant association between the latter parameters and sitting time in hours (log C-reactive protein [Beta =0.07], log homeostasis model assessment of insulin resistance index [Beta = 0.05], triglyceride/high-density lipoprotein cholesterol ratio [Beta = 0.23], and insulin [Beta = 0.44]), which remained after adjustment for metabolic equivalents-h/week. Workers who spend more time sitting show a worse inflammatory and insulin resistance profile independently of the physical activity performed.