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ARS Home » Plains Area » Grand Forks, North Dakota » Grand Forks Human Nutrition Research Center » Dietary Prevention of Obesity-related Disease Research » Research » Publications at this Location » Publication #313073
Title: Enhanced bioavailability of EPA from emulsified fish oil preparations versus capsular triacylglycerol

Author
item Raatz, Susan
item JOHNSON, LUANN - University Of North Dakota
item BIBUS, DOUGLAS - Lipid Technologies
item Bukowski, Michael

Submitted to: Lipids Journal
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 11/12/2015
Publication Date: 5/2/2016
Publication URL: https://handle.nal.usda.gov/10113/62485
Citation: Raatz, S.K., Johnson, L.K., Bibus, D.M., Bukowski, M.R. 2016. Enhanced bioavailability of EPA from emulsified fish oil preparations versus capsular triacylglycerol. Lipids Journal. 51(5):643-651.

Interpretive Summary: For those individuals who are unable to consume adequate long chain omega-3 fatty acids (LCn3) from dietary sources, fish oil supplementation is an attractive alternative. Pre-emulsified fish oil supplements, an alternative to capsular triacylglycerol, may enhance the uptake of LCn3 fatty acids it contains. A randomized, Latin-square crossover design was used to compare the effects of four fish oil supplement preparations (Emulsions S, B and N) on phospholipid (PLFA) and chylomicron fatty acid (CMFA) concentrations in 10 healthy volunteers compared to oil capsules over 48 hours after a single dose. Blood samples were collected at 0, 2, 4, 8, 24 and 48 hours and fatty acid concentrations of PLFA and CMFA were determined by gas chromatography and the integrated area under the curve over 40 hours (iAUC0-48) was determined. Emulsion S and Emulsion N promoted increased uptake of EPA into PLFA over 48 hours when evaluating by iAUC0-48 or individual time points of assessment. No differences were observed between supplements in the CMFA concentrations.

Technical Abstract: Pre-emulsified fish oil supplements, an alternative to capsular triacylglycerol, may enhance the uptake of LCn3 fatty acids it contains. A randomized, Latin-square crossover design was used to compare the effects of four fish oil supplement preparations on phospholipid (PLFA) and chylomicron fatty acid (CMFA) concentrations in 10 healthy volunteers compared to oil capsules over 48 hours after a single dose. Blood samples were collected at 0, 2, 4, 8, 24 and 48 hours and fatty acid concentrations of PLFA and CMFA were determined by gas chromatography and the integrated area under the curve over 40 hours (iAUC0-48) was determined. Emulsion S and Emulsion N promoted increased uptake of EPA into PLFA over 48 hours. No differences were observed between supplements in the CMFA concentrations.