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ARS Home » Pacific West Area » Logan, Utah » Poisonous Plant Research » Research » Publications at this Location » Publication #317120
Title: A survey of tremetone, dehydrotremetone and structurally related compounds in Isocoma spp. (Goldenbush) in the southwestern United States

Author
item Lee, Stephen
item Cook, Daniel
item Davis, Thomas - Zane
item Gardner, Dale
item JOHNSON, ROBERT - Brigham Young University
item Stonecipher, Clinton - Clint

Submitted to: Journal of Agricultural and Food Chemistry
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 1/2/2015
Publication Date: 3/4/2015
Publication URL: https://handle.nal.usda.gov/10113/62818
Citation: Lee, S.T., Cook, D., Davis, T.Z., Gardner, D.R., Johnson, R.L., Stonecipher, C.A. 2015. A survey of tremetone, dehydrotremetone and structurally related compounds in Isocoma spp. (Goldenbush) in the southwestern United States. Journal of Agricultural and Food Chemistry. 63(3):872-879.

Interpretive Summary: Isocoma pluriflora, a plant prevalent on land used for livestock production and native to Arizona, New Mexico, West Texas and Northern Mexico is poisonous to livestock. Tremetone and dehydrotremetone have been suggested as the toxic compounds in I. pluriflora. In this study several different Isocoma spp. including I. pluriflora, I. tenuisecta, I. azteca, I. acradenia, and I. rusbyi, that are native to land used for grazing livestock in the southwestern United States were analyzed by high performance liquid chromatography for tremetone, dehydrotremetone, and other structurally related compounds. This is the first report of tremetone, dehydrotremetone, and 3-oxyangeloyltremetone in I. tenuisecta, I. azteca, I. acradenia, I. rusbyi, and several other Isocoma spp. In addition, this is the first report of 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone and 7-isopentenyloxycoumarin in Isocoma spp.

Technical Abstract: Isocoma plurif lora, a plant prevalent on land used for livestock production and native to Arizona, New Mexico, West Texas, and Northern Mexico, is poisonous and causes trembles in livestock. Tremetone and dehydrotremetone have been suggested as the toxic compounds in I. plurif lora. In this study several different Isocoma spp., including I. plurif lora, I. tenuisecta, I. azteca, I. acradenia, and I. rusbyi, that are native to land used for grazing livestock in the southwestern United States were analyzed by high performance liquid chromatography (HPLC) for tremetone, dehydrotremetone, and other structurally related compounds. This is the first report of tremetone, dehydrotremetone, and 3-oxyangeloyltremetone in I. tenuisecta, I. azteca, I. acradenia, I. rusbyi, and several other Isocoma spp. In addition, this is the first report of 4-hydroxy-3-(3-methyl-2-butenyl)acetophenone and 7-isopentenyloxycoumarin in Isocoma spp.