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ARS Home » Northeast Area » Beltsville, Maryland (BARC) » Beltsville Agricultural Research Center » Animal Parasitic Diseases Laboratory » Research » Publications at this Location » Publication #319205
Title: QS-21: a potent vaccine adjuvant

Author
item Tuo, Wenbin
item ZHU, DAMING - National Instiute Of Allergy And Infectious Diseases (NIAID, NIH)

Submitted to: Comprehensive Natural Products Chemistry
Publication Type: Review Article
Publication Acceptance Date: 7/28/2015
Publication Date: 5/20/2016
Citation: Tuo, W., Zhu, D. 2016. QS-21: a potent vaccine adjuvant. Comprehensive Natural Products Chemistry. 3(4):e113.

Interpretive Summary: QS-21 is a vaccine adjuvant derived from the bark of a Chilean tree, Quillaja saponaria. One of the advantages of this product in vaccine applications is that it favors both humoral and cell-mediaed immunity can be widely applicable to a variety of vaccine applications. This adjuvant has been used for some veterinary vaccines and may be approved for human use in the near future. This information is useful to researchers in vaccine research and development and the producers in need for livestock vaccines.

Technical Abstract: QS-21 is an potent adjuvant derived from the bark of a Chilean tree, Quillaja saponaria. One of the advantages of this adjuvant is that it promotes a balanced humoral and cell-mediaed immune response and can be widely applicable to a variety of vaccines. This adjuvant has used for some veterinary vaccines and may be approved for human use in the near future.