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ARS Home » Southeast Area » Fort Pierce, Florida » U.S. Horticultural Research Laboratory » Citrus and Other Subtropical Products Research » Research » Publications at this Location » Publication #319239
Title: Citrus flavanones prevent systemic inflammation and ameliorate oxidative stress in C57BL/6J mice fed high fat diet

Author
item FERREIRA, PAULA - Sao Paulo State University (UNESP)
item SPOLIDORIO, LUIS - Sao Paulo State University (UNESP)
item Manthey, John
item CESAR, THAIS - Sao Paulo State University (UNESP)

Submitted to: Food & Function
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 5/9/2016
Publication Date: 6/15/2016
Citation: Ferreira, P., Spolidorio, L., Manthey, J.A., Cesar, T. 2016. Citrus flavanones prevent systemic inflammation and ameliorate oxidative stress in C57BL/6J mice fed high fat diet. Food & Function. 7(6):2675-2681. doi: 10.1039/c5fo01541c.

Interpretive Summary: High fat diets cause chronic, damaging inflammation to internal organs in animals. Certain health beneficial citrus compounds were fed to rats given high fat diets. The results showed that the citrus compounds have protective effects against inflammation and oxidative stress caused by high-fat diets and therefore prevent alterations associated with the development of cardiovascular disease.

Technical Abstract: It was investigated the preventive effects of the flavanones hesperidin, eriocitrin and eriodictyol on the oxidative stress and systemic inflammation induced by high-fat diet in C57BL/6J mice. The mice received a standard diet (9.5% kcal from fat), high-fat diet (45% kcal from fat) or high fat diet supplemented with hesperidin, eriocitrin or eriodictyol for a period of four weeks. Hesperidin, eriocitrin and eriodictyol increased the serum total antioxidant capacity, and prevented the elevation of interleukin-6 (IL-6), macrophage chemoattractant protein-1 (MCP-1), and C-reactive protein (hs-CRP) in the blood serum. In addition, the liver TBARS levels and spleen mass (g/kg body weight) were lesser than the unsupplemented mice. Eriocitrin and eriodictyol also reduced TBARS levels in the blood serum, while hesperidin and eriodictyol reduced fat accumulation and liver damage. The results showed that hesperidin, eriocitrin or eriodictyol have protective effects against inflammation and oxidative stress caused by high-fat diet and, therefore, preventing metabolic alterations associated with the development of cardiovascular diseases.