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ARS Home » Research » Publications at this Location » Publication #32241
Title: EFFECTS OF SELECTIVE DEPLETION OF T LYMPHOCYTE POPULATIONS ON EIMERIA ACERVULINA AND EIMERIA TENELLA INFECTION

Author
item TROUT JAMES M - 1265-40-00
item LILLEHOJ HYUN S - 1265-40-00

Submitted to: Poultry Science Association Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 9/1/1994
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: We evaluated the effects of selective T cell depletion on Eimeria infection. Cell depletions were initiated in day- or week-old SC strain chickens using intraperitoneal injections of monoclonal antibodies to CD4, CD8, or TCR2. Control birds received irrelevant antibody or PBS. All birds received primary infections of 1 x 10 4 and secondary infections of 1 x 10 5 E. acervulina or E. tenella oocysts. Oocyst production in CD4 depleted birds was higher than controls for both primary and secondary infections; however, oocyst production was lower during secondary than primary infection indicating that immunity had developed. Compared to controls, oocyst production in CD8 and TCR2 depleted birds was lower during primary but higher during secondary infection. Within CD8 depleted groups, oocyst production was higher for secondary than for primary infection indicating that immunity did not develop. The decreased oocyst production in primary infection of CD8 depleted birds may be related to the potential role of CD8+ cells in sporozoite transport; the apparent lack of a secondary response indicate CD8+ cells protect against reinfection.