Author
![]() |
Dickey, Aaron |
![]() |
LOY, JOHN - University Of Nebraska |
![]() |
Bono, James - Jim |
![]() |
Smith, Timothy - Tim |
![]() |
APLEY, MIKE - Kansas State University |
![]() |
LUBBERS, BRIAN - Kansas State University |
![]() |
DEDONDER, KEITH - Kansas State University |
![]() |
CAPIK, SARAH - Kansas State University |
![]() |
LARSON, ROBERT - Kansas State University |
![]() |
WHITE, BRAD - Kansas State University |
![]() |
BLOM, JOCHEN - University Of Giessen |
![]() |
Chitko-Mckown, Carol |
![]() |
Clawson, Michael - Mike |
Submitted to: Veterinary Research
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 1/22/2016 Publication Date: 2/13/2016 Publication URL: https://handle.nal.usda.gov/10113/61887 Citation: Dickey, A.M., Loy, J.D., Bono, J.L., Smith, T.P.L., Apley, M.D., Lubbers, B.V., DeDonder, K.D., Capik, S.F., Larson, R.L., White, B.J., Blom, J., Chitko-McKown, C.G., Clawson, M.L. 2016. Large genomic differences between Moraxella bovoculi isolates acquired from the eyes of cattle with conjunctivitis versus the deep nasopharynx of asymptomatic cattle. Veterinary Research. 47:31. Interpretive Summary: Moraxella bovoculi is a recently described bacterium that is associated with "pinkeye" in cattle. In this study, finished genomes were sequenced for seven M. bovoculi isolates: three that originated from the eyes of clinical pinkeye cases and four from the nasopharynx of asymptomatic cattle. Isolates that originated from clinical cases were profoundly different from those sampled from asymptomatic cattle in genome structure, gene content and polymorphism diversity and the two types placed into distinct genetic groups. These results suggest that there are genetically distinct strains of M. bovoculi that may not associate with pinkeye in cattle. Technical Abstract: Moraxella bovoculi is a recently described bacterium that is associated with infectious bovine keratoconjunctivitis (IBK) or "pinkeye" in cattle. In this study, closed circularized genomes were generated for seven M. bovoculi isolates: three that originated from the eyes of clinical IBK bovine cases and four from the deep nasopharynx of asymptomatic cattle. Isolates that originated from clinical cases were profoundly different from those sampled from asymptomatic cattle in genome structure, gene content and polymorphism diversity and the two types placed into distinct phylogenetic groups. These results suggest that there are genetically distinct strains of M. bovoculi that may not associate with IBK. |