Author
Danforth, Harry | |
Augustine, Patricia | |
CLARE R L - SMITHKLINE BEECHAM ANML |
Submitted to: American Association of Veterinary Parasitologists Proceedings
Publication Type: Abstract Only Publication Acceptance Date: 7/1/1994 Publication Date: N/A Citation: N/A Interpretive Summary: Technical Abstract: A line of broiler birds was used to evaluate the effect of Freund's complete (FCA) and Amphigen adjuvants and bird sex in battery and floorpen immunization studies with a combination of three recombinant antigens (RA). Male birds were found to have increased nonspecific immune response as measured by weight gain and feed conversion to coccidial challenge with FCA when compared to female birds in battery trials. No such increase in nonspecific immune response to challenge was seen with either sex with Amphigen. Subsequent battery and floorpen trails both showed significant elicited protection in male birds against challenge by two different species of coccidia after immunization with the 3 RA antigens and Amphigen. Protection with female birds only occurred with challenge of one coccidial species. Although the FCA demonstrated a protective response in both sexes of birds with the RA antigens against both coccidial species, the nonspecific response in sham-immunized birds was significantly higher than unimmunized-inoculated controls. This result made it difficult to interpret the degree of elicited protective immune response of the RA antigens and FCA. |