Microbial-derived products as potential new antimicrobials: A report from the Second Alternatives to Antibiotics Symposium

Authors: SEAL, BRUCE - Oregon State University; DRIDER, DJAMEL - Universite De Lille; OAKLEY, BRIAN - Western University Of Health Sciences; BRUSSOW, HARALD - Nestle; BICKARD, DAVID - Institut Pasteur - France; Rich, Joseph; MILLER, STEFAN - Lisando Gmbh; DEVILLARD, ESTELLE - Adisseo France Sas; KWAN, JASON - University Of Wisconsin; BERTIN, GERARD - Erawan Consulting; REEVES, STUART - Embria Health Sciences; Swift, Steven; RAICEK, MARGOT - World Organization For Animal Health; Gay, Cyril

Submitted to: Veterinary Research
Publication Type: Review Article
Publication Acceptance Date: 2/1/2018
Publication Date: 7/31/2018
Citation: Seal, B.S., Drider, D., Oakley, B.B., Brussow, H., Bickard, D., Rich, J.O., Miller, S., Devillard, E., Kwan, J., Bertin, G., Reeves, S., Swift, S.M., Raicek, M., Gay, C.G. 2018. Microbial-derived products as potential new antimicrobials: A report from the Second Alternatives to Antibiotics Symposium. Veterinary Research. 49:66. 10.1186/s13567-018-0563-5.
DOI: https://doi.org/10.1186/s13567-018-0563-5

Interpretive Summary:

Technical Abstract: Due to the continuing global concerns involving antibiotic resistance, there is a need for scientific forums to assess advancements in the development of antimicrobials and their alternatives that might reduce development and spread of antibiotic resistance among bacterial pathogens. The objectives of the Second International Symposium on Alternatives to Antibiotics were to highlight promising research results and novel technologies that can provide alternatives to antibiotics for use in animal health and production, assess challenges associated with their authorization and commercialization for use, and provide actionable strategies to support their development. The session on microbial-derived products was directed at presenting novel technologies that included exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials, probiotics development via fecal microbiome transplants among monogastric production animals such as chickens and mining microbial sources such as bacteria or yeast to identify new antimicrobial compounds. Other research has included continuing development of antimicrobial peptides such as newly discovered bacteriocins as alternatives to antibiotics, use of bacteriophages accompanied by development of unique lytic proteins with specific cell-wall binding domains, and novel approaches such as microbial-ecology guided discovery of anti-biofilm compounds discovered in marine environments. The symposium was held at the Headquarters of the World Organisation for Animal Health (OIE) in Paris, France during 12-15 December 2016, and information including presentation materials for the symposium can be accessed at: https://www.ars.usda.gov/alternativestoantibiotics/Symposium2016/index.html.