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ARS Home » Plains Area » Clay Center, Nebraska » U.S. Meat Animal Research Center » Animal Health Genomics » Research » Publications at this Location » Publication #344890
Research Project: Genomic Intervention Strategies to Prevent and/or Treat Respiratory Diseases of Ruminants

Location: Animal Health Genomics

Title: Closed genome sequences of seven histophilus somni isolates from beef calves with bovine respiratory disease complex

Author
item Harhay, Gregory
item Harhay, Dayna
item Bono, James - Jim
item Smith, Timothy - Tim
item CAPIK, SARAH - Texas A&M Agrilife
item DEDONDER, KEITH - Veterinary And Biomedical Research Center, Inc
item APLEY, MICHAEL - Kansas State University
item LUBBERS, BRIAN - Kansas State University
item WHITE, BRADLEY - Kansas State University
item LARSON, ROBERT - Kansas State University

Submitted to: Genome Announcements
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 9/6/2017
Publication Date: 10/5/2017
Publication URL: https://handle.nal.usda.gov/10113/6472416
Citation: Harhay, G.P., Harhay, D.M., Bono, J.L., Smith, T.P.L., Capik, S.F., DeDonder, K.D., Apley, M.D., Lubbers, B.V., White, B.J., Larson, R.L. 2017. Closed genome sequences of seven histophilus somni isolates from beef calves with bovine respiratory disease complex. Genome Announcements. 5(40):e01099-17. https://doi.org/10.1128/genomeA.01099-17.
DOI: https://doi.org/10.1128/genomeA.01099-17

Interpretive Summary: Bovine respiratory disease complex outbreaks in feed yard cattle are the primary drivers of disease-related antibiotic treatments and have a global impact estimated to be greater than $USD 3 billion/year. Histophilus somni is a disease-causing bacterium that affects multiple organ systems and is one of the principle species contributing to bovine respiratory disease complex (BRDC) in feed yard cattle. There is a need for more publicly available H. somni closed genomes because only two were available in GenBank as of January 2016. These closed genomes provide important information to veterinary microbiologists and other veterinary medical professionals about H. somni’s potential to cause disease.

Technical Abstract: Histophilus somni is a fastidious Gram-negative opportunistic pathogenic Pasteurellacea that affects multiple organ systems and is one of the principle bacterial species contributing to bovine respiratory disease complex (BRDC) in feed yard cattle. Here, we present seven closed genome sequences isolated from three beef calves showing sign of BRDC.