Author
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JAMES-TODD, TAMARRA - Harvard School Of Public Health |
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HULL, HOLLY - Kansas State University |
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ANDRES, ALINE - Arkansas Children'S Nutrition Research Center (ACNC) |
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Submitted to: Meeting Abstract
Publication Type: Abstract Only Publication Acceptance Date: 9/1/2017 Publication Date: N/A Citation: N/A Interpretive Summary:
Technical Abstract: Phthalates are endocrine-disrupting chemicals associated with childhood obesity. While studies have found positive associations for certain prenatal and postnatal urinary phthalate metabolites and weight/length or BMI as indicators of adiposity levels, little is known about the direct associations between phthalates and fat accretion in early life. This study measured prenatal phthalate urine metabolite concentrations and infant fat mass (FM) across 12-months. Using a prospective design, a total of 20 white mothers were included based on their pre-pregnancy body mass index (BMI) and FM (n=10 obese: >30kg/m2and >30% FM; n=10 normal weight: <25kg/m2 and <30% FM). Urine was collected at 30 weeks gestation and analyzed for 9 urinary phthalate metabolites and divided at the median. Children's FM were obtained at 2-weeks, 6-months, and 12-months of age using quantitative magnetic resonance. ANOVA and generalized linear models evaluated the associations between prenatal phthalate metabolite concentrations and infant FM measures, while adjusting for potential confounders (maternal BMI, FM, and gestational weight gain). Higher than median concentrations of mono-(3-carboxypropyl) phthalate (MCPP) was associated with higher infant FM at 6-months and 12-months of age (p<0.03). Higher mono-ethyl phthalate (MEP) concentrations were associated with lower infant FM at 12 months (p=0.008). After adjusting for confounders, infants born to mothers with > median MCPP levels had a 4.2% higher FM at 12-months compared to infants born to mothers with |
