Control of Newcastle disease virus

Authors: Suarez, David

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 3/1/2018
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Newcastle disease virus (NDV), also know as avian paramyxovirus serotype 1, is an important poultry pathogen worldwide. In naive poultry, the virulent forms of the virus cause high mortality. Because of this the virus is reportable to the World Organization for Animal Health and can be an important impediment to trade of poultry and poultry products. The primary method of control of the virus is through the use of vaccines, both live attenuated viruses and killed vaccines. The live attenuated vaccines can provide good protection and can be given by mass vaccination programs, including water administration and by aerosol. Vaccine reactions to the live vaccines are the major impediment of use. The killed vaccines must be given by injection, but the killed vaccines give high levels of neutralizing antibodies. For long lived birds or breeders, a combination of live and killed vaccines are often used. Recently, viral vectored vaccines have started to be used more commonly. The use of herpesvirus of turkeys and fowlpox vectors expressing the fusion gene from NDV are available commercially. These vaccines aren't as protective, but they can be given in the hatchery and have little vaccine reactions. Despite the availability of good vaccines, NDV is still a problem, particularly in Africa and Asia, where vaccines are not as available.