Location: Cotton Chemistry and Utilization Research
Title: Structure/function relations of hemostatic nonwoven dressings based on greige cottonAuthor
![]() |
Edwards, Judson - Vince |
![]() |
Graves, Elena |
![]() |
Reynolds, Michael |
![]() |
Condon, Brian |
![]() |
YAGER, DORNE - Virginia Commonwealth University |
![]() |
DACORTA, JOSEPH - H&h Medical Corporation |
Submitted to: Meeting Proceedings
Publication Type: Proceedings Publication Acceptance Date: 4/1/2018 Publication Date: 5/15/2018 Citation: Edwards, J.V., Graves, E.E., Reynolds, M.L., Condon, B.D., Yager, D., Dacorta, J. 2018. Structure/function relations of hemostatic nonwoven dressings based on greige cotton. In: Proceedings of the American Association of Textile Chemists and Colorists (AATCC) International Conference, March 6-8, 2018, Greenville, South Carolina. p. 1-9. Interpretive Summary: Technical Abstract: A variety of natural and synthetic fibers are employed in hemostatic dressings. Here we demonstrate the use of greige cotton as a functional fiber, which when combined with hydrophilic and hydrophobic fibers in hydroentangled nonwoven materials, promotes accelerated clotting. A biophysical approach was developed to identify fiber compositions that promote hemostasis. The structure/function characterization of greige cotton-based dressings was based on the relationship of material electrokinetics to the rate of fibrin and clot formation. When coupled to material absorption capacity and wicking determinations, materials that promote a rapid onset of clotting were identified. In vitro assessment of whole materials that promote hemostasis was completed using the Lee White Clotting assay to provide a structure versus function profile of hemostatic activity for selection of leads. |