Structure/function relations of hemostatic nonwoven dressings based on greige cotton

Authors: Edwards, Judson - Vince; Graves, Elena; Reynolds, Michael; Condon, Brian; YAGER, DORNE - Virginia Commonwealth University; DACORTA, JOSEPH - H&h Medical Corporation

Submitted to: Meeting Proceedings
Publication Type: Proceedings
Publication Acceptance Date: 4/1/2018
Publication Date: 5/15/2018
Citation: Edwards, J.V., Graves, E.E., Reynolds, M.L., Condon, B.D., Yager, D., Dacorta, J. 2018. Structure/function relations of hemostatic nonwoven dressings based on greige cotton. In: Proceedings of the American Association of Textile Chemists and Colorists (AATCC) International Conference, March 6-8, 2018, Greenville, South Carolina. p. 1-9.

Interpretive Summary:

Technical Abstract: A variety of natural and synthetic fibers are employed in hemostatic dressings. Here we demonstrate the use of greige cotton as a functional fiber, which when combined with hydrophilic and hydrophobic fibers in hydroentangled nonwoven materials, promotes accelerated clotting. A biophysical approach was developed to identify fiber compositions that promote hemostasis. The structure/function characterization of greige cotton-based dressings was based on the relationship of material electrokinetics to the rate of fibrin and clot formation. When coupled to material absorption capacity and wicking determinations, materials that promote a rapid onset of clotting were identified. In vitro assessment of whole materials that promote hemostasis was completed using the Lee White Clotting assay to provide a structure versus function profile of hemostatic activity for selection of leads.