Author
BLANTON, LAURA - Washington University School Of Medicine | |
CHARBONNEAU, MARK - Washington University School Of Medicine | |
SALIH, TAREK - Washington University School Of Medicine | |
BARRATT, MICHAEL - Washington University School Of Medicine | |
VENKATESH, SIDDARTH - Washington University School Of Medicine | |
ILKAVEYA, OLGA - Duke University Medical Center | |
SUBRAMANIAN, SATHISH - Washington University School Of Medicine | |
MANARY, MARK - Children'S Nutrition Research Center (CNRC) | |
TREHAN, INDI - Washington University School Of Medicine | |
JORGENSEN, JOSH - University Of California, Davis | |
FAN, YUE-MEI - University Of Tampere Medical School | |
HENRISSAT, BERNARD - King Abdulaziz University | |
LEYN, SEMEN - Russian Academy Of Sciences | |
RODIONOV, DMITRY - Russian Academy Of Sciences | |
OSTERMAN, ANDREI - Sanford And Burnham Medical Research Institute | |
MALETA, KENNETH - University Of Malawi | |
NEWGARD, CHRISTOPHER - Duke University Medical Center | |
ASHORN, PER - University Of Tampere Medical School | |
DEWEY, KATHRYN - University Of California, Davis | |
GORDON, JEFFREY - Washington University School Of Medicine |
Submitted to: Science
Publication Type: Peer Reviewed Journal Publication Acceptance Date: 12/23/2015 Publication Date: 2/19/2016 Citation: Blanton, L.V., Charbonneau, M.R., Salih, T., Barratt, M.J., Venkatesh, S., Ilkaveya, O., Subramanian, S., Manary, M.J., Trehan, I., Jorgensen, J.M., Fan, Y., Henrissat, B., Leyn, S.A., Rodionov, D.A., Osterman, A.L., Maleta, K.M., Newgard, C.B., Ashorn, P., Dewey, K.G., Gordon, J.I. 2016. Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science. 351(6275):aad3311. https://doi.org/10.1126/science.aad3311. DOI: https://doi.org/10.1126/science.aad3311 Interpretive Summary: Gut microbes in undernourished children are weak and underdeveloped. Transplanting microbes from undernourished Malawian children into young mice fed the same Malawian diet decreased their growth. These results provide evidence that poor microbe health is related to undernutrition and must be further explored. Technical Abstract: Undernourished children exhibit impaired development of their gut microbiota. Transplanting microbiota from 6- and 18-month-old healthy or undernourished Malawian donors into young germ-free mice that were fed a Malawian diet revealed that immature microbiota from undernourished infants and children transmit impaired growth phenotypes. The representation of several age-discriminatory taxa in recipient animals correlated with lean body mass gain; liver, muscle, and brain metabolism; and bone morphology. Mice were cohoused shortly after receiving microbiota from healthy or severely stunted and underweight infants; age- and growth-discriminatory taxa from the microbiota of the former were able to invade that of the latter, which prevented growth impairments in recipient animals. Adding two invasive species, Ruminococcus gnavus and Clostridium symbiosum, to the microbiota from undernourished donors also ameliorated growth and metabolic abnormalities in recipient animals. These results provide evidence that microbiota immaturity is causally related to undernutrition and reveal potential therapeutic targets and agents. |