Author
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MANARY, MARK - Children'S Nutrition Research Center (CNRC) |
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Submitted to: Cellular and Molecular Gastoenterology and Hepatology
Publication Type: Other Publication Acceptance Date: 3/3/2016 Publication Date: 5/1/2016 Citation: Manary, M. 2016. The paneth cell: A guardian of gut health. Cellular and Molecular Gastoenterology and Hepatology. 2(3):259. https://doi.org/10.1016/j.jcmgh.2016.02.001. DOI: https://doi.org/10.1016/j.jcmgh.2016.02.001 Interpretive Summary: Technical Abstract: The article by Podany et al in the current issue of Cellular and Molecular Gastroenterology and Hepatology makes observations that significantly advance our understanding of Paneth cells and zinc transporters in maintenance of a healthy gut barrier and microbiota of the small intestine. Paneth cells secrete large quantities of antimicrobial enzymes, cytokines, and hormones, and are found in increasing numbers in the ileum, the section of the small intestine with the most microbes. Paneth cells contain relatively large amounts of zinc in secretory granules and it is speculated that this zinc allows for optimal stabilization and function of these secreted macromolecules. Paneth cells sense populations of microbiota through Toll-like receptors, and respond with release of their bactericidal granules. |
