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Research Project: Headquarters Cooperative Programs - Animal Production and Protection (APP)

Location: Animal Production and Protection

Title: Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions

Author
item HOELZER, KARIN - Pew Charitable Trusts
item BIELKE, LISA - The Ohio State University
item BLAKE, DAMER - University Of London
item COX, ERIC - Ghent University
item CUTTING, SIMON - University Of London
item DEVRIENDT, BERT - Ghent University
item ERLACHER-VINDEL, ELISABETH - World Organization For Animal Health
item GOSSENS, EVY - Ghent University
item KARACA, KEMAL - Elanco Animal Health, Inc
item LEMIERE, STEPHANE - Merial, Ltd
item METZNER, MARTIN - Ripac-Labor Gmbh
item RAICEK, MARGOT - World Organization For Animal Health
item SURINACH, MIQUEL - Msd
item WONG, NORA - Pew Charitable Trusts
item Gay, Cyril
item VAN IMMERSEEL, FILIP - Ghent University

Submitted to: Veterinary Research
Publication Type: Review Article
Publication Acceptance Date: 12/22/2017
Publication Date: 7/31/2018
Citation: Hoelzer, K., Bielke, L., Blake, D.P., Cox, E., Cutting, S.M., Devriendt, B., Erlacher-Vindel, E., Gossens, E., Karaca, K., Lemiere, S., Metzner, M., Raicek, M., Surinach, M.C., Wong, N., Gay, C.G., Van Immerseel, F. 2018. Vaccines as alternatives to antibiotics for food producing animals. Part 2: new approaches and potential solutions. Veterinary Research. https://doi.org/10.1186/s13567-018-0561-7.
DOI: https://doi.org/10.1186/s13567-018-0561-7

Interpretive Summary: Vaccines and other alternative products are central to the future success of animal agriculture because they can help minimize the need for antibiotics by preventing and controlling infectious diseases in animal populations. To assess scientific advancements related to alternatives to antibiotics and provide actionable strategies to support their development, the United States Department of Agriculture, with support from the World Organisation for Animal Health, organized the second International Symposium on Alternatives to Antibiotics. It focused on six key areas: vaccines; microbial-derived products; non-nutritive phytochemicals; immune-related products; chemicals, enzymes, and innovative drugs; and regulatory pathways to enable the development and licensure of alternatives to antibiotics. This article, the second part in a two-part series, highlights new approaches and potential solutions for the development of vaccines as alternatives to antibiotics in food producing animals; opportunities, challenges and needs for the development of such vaccines are discussed in the first part of this series. As discussed in part 1 of this manuscript, many current vaccines fall short of ideal vaccines in one or more respects. Promising breakthroughs to overcome these limitations include new biotechnology techniques, new oral vaccine approaches, novel adjuvants, new delivery strategies based on bacterial spores, and live recombinant vectors; they also include new vaccination strategies in-ovo, and strategies that simultaneously protect against multiple pathogens. However, translating this research into commercial vaccines that effectively reduce the need for antibiotics will require close collaboration among stakeholders, for instance through public–private partnerships. Targeted research and development investments and concerted efforts by all affected are needed to realize the potential of vaccines to improve animal health, safeguard agricultural productivity, and reduce antibiotic consumption and resulting resistance risks.

Technical Abstract: Vaccines and other alternative products are central to the future success of animal agriculture because they can help minimize the need for antibiotics by preventing and controlling infectious diseases in animal populations. To assess scientific advancements related to alternatives to antibiotics and provide actionable strategies to support their development, the United States Department of Agriculture, with support from the World Organisation for Animal Health, organized the second International Symposium on Alternatives to Antibiotics. It focused on six key areas: vaccines; microbial-derived products; non-nutritive phytochemicals; immune-related products; chemicals, enzymes, and innovative drugs; and regulatory pathways to enable the development and licensure of alternatives to antibiotics. This article, the second part in a two-part series, highlights new approaches and potential solutions for the development of vaccines as alternatives to antibiotics in food producing animals; opportunities, challenges and needs for the development of such vaccines are discussed in the first part of this series. As discussed in part 1 of this manuscript, many current vaccines fall short of ideal vaccines in one or more respects. Promising breakthroughs to overcome these limitations include new biotechnology techniques, new oral vaccine approaches, novel adjuvants, new delivery strategies based on bacterial spores, and live recombinant vectors; they also include new vaccination strategies in-ovo, and strategies that simultaneously protect against multiple pathogens. However, translating this research into commercial vaccines that effectively reduce the need for antibiotics will require close collaboration among stakeholders, for instance through public–private partnerships. Targeted research and development investments and concerted efforts by all affected are needed to realize the potential of vaccines to improve animal health, safeguard agricultural productivity, and reduce antibiotic consumption and resulting resistance risks.