Skip to main content
ARS Home » Midwest Area » Ames, Iowa » National Animal Disease Center » Virus and Prion Research » Research » Publications at this Location » Publication #359422
Research Project: Intervention Strategies to Control Influenza A Virus Infection in Swine

Location: Virus and Prion Research

Title: Adaptation of human influenza viruses to swine

Author
item RAJAO, DANIELA - University Of Georgia
item Baker, Amy
item PEREZ, DANIEL - University Of Georgia

Submitted to: Frontiers in Veterinary Science
Publication Type: Review Article
Publication Acceptance Date: 12/31/2018
Publication Date: 11/22/2019
Citation: Rajao, D.S., Vincent, A.L., Perez, D.R. 2019. Adaptation of human influenza viruses to swine. Frontiers in Veterinary Science. 5:347. https://doi.org/10.3389/fvets.2018.00347.
DOI: https://doi.org/10.3389/fvets.2018.00347

Interpretive Summary:

Technical Abstract: A large diversity of influenza A viruses (IAV) within the H1N1/N2 and H3N2 subtypes circulates in pigs globally, with different lineages predominating in specific regions of the globe. A common characteristic of the ecology of IAV in swine in different regions is the periodic spillover of human seasonal viruses. Such human viruses resulted in sustained transmission in swine in several countries, leading to the establishment of novel IAV lineages in the swine host and contributing to the genetic and antigenic diversity of influenza observed in pigs. In this review we discuss the frequent occurrence of reverse-zoonosis of IAV from humans to pigs that have contributed to the global viral diversity in swine in a continuous manner, describe host-range factors that may be related to the adaptation of these human-origin viruses to pigs, and how these events could affect the swine industry.