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ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #364163
Research Project: Discovery and Development of Natural Products for Pharmaceutical and Agrochemical Applications II

Location: Natural Products Utilization Research

Title: Anthraquinone-based specialized metabolites from rhizomes of Bulbine natalensis

Author
item BAE, JI-YEONG - University Of Mississippi
item ALI, ZULFIQAR - University Of Mississippi
item WANG, YAN-HONG - University Of Mississippi
item CHITTIBOYINA, AMAR - University Of Mississippi
item ZAKI, AHMED - University Of Mississippi
item VILJEON, ALVARO - Tshwane University
item KHAN, IKHLAS - University Of Mississippi

Submitted to: Journal of Natural Products
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 4/9/2019
Publication Date: 7/9/2019
Citation: Bae, J., Ali, Z., Wang, Y., Chittiboyina, A.G., Zaki, A.A., Viljeon, A.M., Khan, I.A. 2019. Anthraquinone-based specialized metabolites from rhizomes of Bulbine natalensis. Journal of Natural Products. 82:1893-1901. https://doi.org/10.1021/acs.jnatprod.9b00187.
DOI: https://doi.org/10.1021/acs.jnatprod.9b00187

Interpretive Summary: Bulbine natalensis is used for the dietary supplements claimed as testosterone booster but the phytochemical study on it has not been done till now. As part of our ongoing efforts to identify constituents from widely used plants in dietary supplements that can be utilized as chemical/biological markers, the phytochemical investigation of the subterranean stems of B. natalensis was performed. The current paper deals with the isolation and structure elucidation of fourteen compounds from the methanol extract of B. natalensis and evaluation of their antimicrobial activity.

Technical Abstract: The subterranean stems of Bulbine natalensis (Asphodelaceae) furnished seven previously undiscovered compounds including anthraquinone derivatives and a naphthalene derivative together with seven known secondary metabolites. Their structures were determined by interpretation of 1D and 2D Nuclear Magnetic Resonance (NMR) and High-Resolution Electrospray Ionisation Mass Spectrometry (HRESIMS) data. The absolute configurations of compounds were determined by specific rotation and circular dichroism experiments. The isolated compounds were evaluated for the antimicrobial activities and compound 1 was found to be a moderate inhibitor (IC50 0.02 µM) against methicillin-resistant Staphylococcus aureus (MRSA).