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Research Project: Intervention Strategies to Support the Global Control and Eradication of Foot-and-Mouth Disease Virus (FMDV)

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Title: First report of near-complete genome sequences of foot-and-mouth disease virus serotype O strains from Kenya

Author
item FISH, IAN - Oak Ridge Institute For Science And Education (ORISE)
item VIERRA, DAVID - Kansas State University
item EHZIBOLO, DAVID - National Veterinary Research Institute
item Palinski, Rachel
item BERTRAM, MIRANDA - Oak Ridge Institute For Science And Education (ORISE)
item Pauszek, Steven
item Hartwig, Ethan
item Smoliga, George
item Arzt, Jonathan

Submitted to: Microbiology Resource Announcements
Publication Type: Other
Publication Acceptance Date: 8/10/2019
Publication Date: 8/29/2019
Citation: Fish, I., Vierra, D., Ehzibolo, D., Palinski, R.M., Bertram, M., Pauszek, S.J., Hartwig, E.J., Smoliga, G.R., Arzt, J. 2019. First report of near-complete genome sequences of foot-and-mouth disease virus serotype O strains from Kenya. Microbiology Resource Announcements. https://doi.org/10.1128/MRA.00808-19.
DOI: https://doi.org/10.1128/MRA.00808-19

Interpretive Summary: Foot-and-mouth disease virus (FMDV) is one of the most economically impactful infectious diseases of livestock, with substantial effects on agriculture and trade. These effects are most evident in countries such as Nigeria where transboundary movement of livestock and incomplete vaccination campaigns are common. This paper is a brief communication describing a newly discovered strain of FMDV from Nigeria. The information herein is completely novel and provides a detailed examination of FMDV genetic information. This will contribute to the understanding of the virus’ spread and evolution within Nigeria and help protect US agriculture from foreign animal disease threats.

Technical Abstract: We report an 8,091 nucleotide near full FMDV genome and partial UTRs of an October 2014 outbreak in in Magama, Bauchi State, Nigeria. Analysis of the VP1 coding sequence of this virus placed it in the SAT2 topotype VII lineage. This genome will contribute to understanding the molecular epidemiology of FMDV in West Africa as part of the pathway to regional control and eradication.