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Title: High-density lipoprotein: our elusive friend

Author
item ASZTALOS, BELA - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item NIISUKE, KATRIN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University
item HORVATH, KATALIN - Jean Mayer Human Nutrition Research Center On Aging At Tufts University

Submitted to: Current Opinion in Lipidology
Publication Type: Review Article
Publication Acceptance Date: 2/1/2019
Publication Date: 8/30/2019
Citation: Asztalos, B.F., Niisuke, K., Horvath, K.V. 2019. High-density lipoprotein: our elusive friend. Current Opinion in Lipidology. 30(4):314-319. https://doi.org/10.1097/MOL.0000000000000612.
DOI: https://doi.org/10.1097/MOL.0000000000000612

Interpretive Summary:

Technical Abstract: PURPOSE OF REVIEW: Despite advances in the research on HDL composition (lipidomics and proteomics) and functions (cholesterol efflux and antioxidative capacities), the relationship between HDL compositional and functional properties is not fully understood. We have reviewed the recent literature on this topic and pointed out the difficulties which limit our understanding of HDL's role in cardiovascular disease (CVD). RECENT FINDINGS: Though current findings strongly support that HDL has a significant role in CVD, the underlying mechanisms by which HDL mitigates CVD risk are not clear. This review focuses on studies that investigate the cell-cholesterol efflux capacity and the proteomic and lipidomic characterization of HDL and its subfractions especially those that analyzed the relationship between HDL composition and functions. SUMMARY: Recent studies on HDL composition and HDL functions have greatly contributed to our understanding of HDL's role in CVD. A major problem in HDL research is the lack of standardization of both the HDL isolation and HDL functionality methods. Data generated by different methods often produce discordant results on the particle number, size, lipid and protein composition, and the various functions of HDL.