Skip to main content
ARS Home » Southeast Area » Oxford, Mississippi » Natural Products Utilization Research » Research » Publications at this Location » Publication #369090
Research Project: Health-Promoting Bioactives and Biobased Pesticides from Medicinal and Herbal Crops

Location: Natural Products Utilization Research

Title: Synthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety

Author
item YU, WEI - ZHEJIANG UNIVERSITY OF TECHNOLOGY
item ZHAI, ZHI-WEN - ZHEJIANG UNIVERSITY OF TECHNOLOGY
item MIN, LI-JING - HUZHOU UNIVERSITY
item WEDGE, DAVID
item DUKE, STEPHEN
item WU, HONG-KE - ZHEJIANG UNIVERSITY OF TECHNOLOGY
item WENG, JIAN-QUAN - ZHEJIANG UNIVERSITY OF TECHNOLOGY
item TAN, CHENG-XIA - ZHEJIANG UNIVERSITY OF TECHNOLOGY
item ZHANG, YONG-GANG - SHANDONG ACADEMY OF AGRICULTURAL SCIENCES
item LIU, XING-HAI - ZHEJIANG UNIVERSITY OF TECHNOLOGY

Submitted to: Research on Chemical Intermediates
Publication Type: Peer Reviewed Journal
Publication Acceptance Date: 8/1/2019
Publication Date: 10/15/2019
Citation: Yu, W., Zhai, Z., Min, L., Wedge, D.E., Duke, S.O., Wu, H., Weng, J., Tan, C., Zhang, Y., Liu, X. 2019. Synthesis and biological activity of novel 1,3,4-oxadiazole derivatives containing a pyrazole moiety. Research on Chemical Intermediates. 45:5989-6001. https://doi.org/10.1007/s11164-019-04015-8.
DOI: https://doi.org/10.1007/s11164-019-04015-8

Interpretive Summary: Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring were designed and synthesized from ethyl acetoacetate and triethyl orthoformate as starting materials via multi-step reactions. These compunds were evaluated for fungicidal and herbicidal activities. Four of the compounds were moderately fungicidal against Colletotrichum species. Most of the compounds had moderate to good activity as a herbicide.

Technical Abstract: Several new 1,3,4-oxadiazole derivatives containing a pyrazole ring were designed and synthesized from ethyl acetoacetate and triethyl orthoformate as starting materials via multi-step reactions. The compound structures were confirmed by melting point, 1H Nuclear Magnetic Resonance (NMR), and High Resolution Mass Spetroscopy (HRMS). They were evaluated for fungicidal and herbicidal activities. Four of the compounds exhibited moderate fungicidal activity against Colletotrichum species. Most of the compounds had moderate to good activity as a herbicide.