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ARS Home » Southeast Area » Athens, Georgia » U.S. National Poultry Research Center » Endemic Poultry Viral Diseases Research » Research » Publications at this Location » Publication #370482
Research Project: Enhancing Genetic Resistance to Marek’s Disease in Poultry

Location: Endemic Poultry Viral Diseases Research

Title: ADPONECTIN AND ITS RECRPTOR GENES EXPRESSION IN RESPONSE TO MDV INFECTION OF WHITE LEGHORNS

Author
item BAI, YING - University Of Maryland
item YUAN, PING - University Of Maryland
item Zhang, Huanmin
item RAMACHANDRAN, RAMESH - China Agricultural University
item YANG, NING - China Agricultural University
item SONG, JIUZHOU - University Of Maryland

Submitted to: Meeting Abstract
Publication Type: Abstract Only
Publication Acceptance Date: 2/26/2020
Publication Date: N/A
Citation: N/A

Interpretive Summary:

Technical Abstract: Marek’s disease virus (MDV) causes T cell lymphoma in susceptible chicken. MDV-infection is also related to an imbalance of the lipid metabolism in infected chickens. Adiponectin is circulatory cytokine secreted from adipose tissue and exerts critical metabolic functions. Although the associations between adiponectin and diseases have been reported, little is known about the relationship between MDV infection and adiponectin. Here, we explored phenotypic characteristics, plasma lipoprotein levels, adiponectin and the levels of its receptors in chicken post MDV infection. Our Data showed that MDV infection induced body weight loss in all the experimental birds. The concentrations of total cholesterol and HDL were lower after the infection. However, the infection did not affect adiponectin circulating levels in plasma. In abdominal fat, there was no significant difference of adiponectin mRNA level but a significant decrease of protein expression in the infected compared to the non-infected susceptible chickens. Moreover, we observed that the adipoR1 and adipoR2 at both mRNA and protein levels were decreased in susceptible chickens post MDV infection. In spleen, MDV infection significantly reduced the adiponectin mRNA expression but increased the protein in susceptible chickens. Furthermore, MDV infection decreased both adipoR1 mRNA expression and protein levels. Also interestingly, the adipoR1 mRNA expression level was significantly increased in susceptible chickens in liver post MDV infection. Taken together, our data provided interesting insights of adiponectin metabolism in chickens in association with MDV infection, which would help us advance the understanding on lipid metabolism in response to avian herpesvirus infection.